HIV Env gp160 585-593 (HLA-A*24:02)

RYLKDQQLL is a linear peptidic epitope (epitope ID56574) studied as part of Envelope glycoprotein gp160 from Human immunodeficiency virus 1. This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays Antigen Peptide HIV Env gp160(585-593) (HLA-A*24:02) RYLKDQQLL for stimulation of antigen-specific T cells in T cell assays such as ELISPOT, ICS, cytotoxity or proliferation assays. Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape. RYLKDQQLL had a significantly positive association with HLA A*23; it was recognized by 6/20 A*23-positive subjects and 20/275 A*23-negative subjects.

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