Cancer
NY-ESO-1 157-165 (HLA-A*02:01) SLLMWITQC
Product number:
EP11374_1
€ 105.00 *
Prices excl. VAT plus shipping
costs
Available, delivery time:
1-3 days
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity:
95% HPLC-MS
Caution:
For research use only. Not for use in humans.
Amount in mg
1
Description
SLLMWITQC is a linear peptidic epitope (epitope ID59278) studied as part of Cancer/testis antigen 1 from Homo sapiens (human). This epitope has been studied for immune reactivity, tested in T cell assays, B cell assays and MHC ligand assays Antigen Peptide NY-ESO-1 157-165 (9C) (HLA-A*02:01) SLLMWITQC for stimulation of antigen-specific T cells in T cell assays such as ELISPOT, ICS, cytotoxity or proliferation assays.
TechData
| Sequence: | SLLMWITQC |
| Gene: | CTAG1A |
| Delivery: | 1-3 days |
| C-Terminus: | OH |
| N-Terminus: | H |
| Amount: | 1 mg |
| Counterion: | TFA |
| Protein: | Cancer testis antigen, NY-ESO-1 |
| Species: | Human |
| Allele: | HLA-A*02:01 |
| Application: | Flow Cytometry |
| Indication: | Cancer |
| Purity: | 95% HPLC-MS |
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NY-ESO-1 157-165 mutant (HLA-A*02:01) 165V
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NY-ESO-1 158-166 (HLA-A*24:02)
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NY-ESO-1 86-94 (HLA-A*02:01)
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NY-ESO-1 86–94 (RLLEFYLAM) is a well-characterized linear peptide epitope derived from the human cancer/testis antigen 1 (NY-ESO-1, UniProt: P78358). Restricted to HLA-A*02:01, this nonamer peptide has been extensively studied for its immunogenic potential in cancer immunology.
According to the Immune Epitope Database (IEDB epitope ID: 1075626), RLLEFYLAM has at least been:
Reported in 6 peer-reviewed publications
Tested in 7 T cell assays, demonstrating strong CD8⁺ T cell reactivity
Assessed in 1 B cell assay and 2 MHC ligand assays
Background on NY-ESO-1 and CTAs
NY-ESO-1 is one of the most immunogenic cancer/testis antigens (CTAs). CTAs are normally expressed only in germ cells of the testis but become aberrantly re-expressed in many cancers, including melanoma, lung, ovarian, and esophageal tumors. Because the testis is an immune-privileged site, the immune system does not develop tolerance to these antigens—making them highly attractive targets for cancer immunotherapy and immune monitoring.
These characteristics have positioned NY-ESO-1, and epitopes like RLLEFYLAM, at the center of research into cancer vaccines, adoptive T cell therapies, and diagnostic assays.
T cell epitope cluster
This peptide is part of an immunodominant cluster. Depending on your HLA-restriction of interest, you might also consider:
NY-ESO-1_LAGE-2 91-101 (YLAMPFATPME) – Optimized for HLA-A*24:02
NY-ESO-1 93-101 (AMPFATPME) – Optimized for HLA-B*07:02
NY-ESO-1 94-102 (MPFATPMEA) – Optimized for HLA-B*35:01 & HLA-B*51:01
peptides&elephants provides NY-ESO-1 86–94 with the highest quality standards, ensuring reliable results in immunological research and translational applications.
NY-ESO-1 93-101 (HLA-B*07:02)
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The peptide epitope NY-ESO-1 93–101 (AMPFATPME) is derived from the human cancer/testis antigen 1 (NY-ESO-1) with the UniProt-ID P78358. This nonamer peptide (IEDB epitope ID: 2265540) is restricted to HLA-B*07:02 and has been investigated for its role in antigen-specific T cell responses in cancer immunology.
NY-ESO-1 and CTAs
NY-ESO-1 belongs to the family of cancer/testis antigens (CTAs), proteins typically restricted to germ cells of the testis but aberrantly expressed in many tumors, including melanoma, lung, ovarian, and esophageal cancers. Because of this unique expression profile and their strong immunogenicity, CTAs like NY-ESO-1 are widely recognized as prime targets for cancer immunotherapy, immune monitoring, and vaccine development.
NY-ESO-1 epitopes such as AMPFATPME contribute to dissecting CD8⁺ T cell responses and advancing the development of diagnostic assays and adoptive T cell therapies.
T cell epitope cluster
This peptide is part of an immunodominant epitope cluster. Depending on your HLA-restriction of interest, you might also consider:NY-ESO-1 86-94 (RLLEFYLAM) – Optimized for HLA-A*02:01NY-ESO-1_LAGE-2 91-101 (YLAMPFATPME) – Optimized for HLA-A*24:02NY-ESO-1 94-102 (MPFATPMEA) – Optimized for HLA-B*35:01 & HLA-B*51:01
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NY-ESO-1 94-102 (HLA-B*35:01) (HLA-B*51:01)
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NY-ESO-1 94-102 (MPFATPMEA) is a specialized nonamer covering the sequence position 94-102 of the human Cancer/Testis Antigen 1 (NY-ESO-1; UniProt: P78358). This epitope is uniquely recognized by human CD8+ T-cells in the context of both HLA-B*35:01 and HLA-B*51:01 molecules.
Key Features:
Dual HLA Restriction: Ideal for research involving diverse donor groups with B35 or B51 backgrounds.
Single-Cell Analysis: Highly effective for the analysis and sorting of individual antigen-specific T-cells via multimer staining or functional assays.
Immunodominant Region: Part of the high-density epitope cluster (aa 86-102), essential for comprehensive epitope mapping.
Applications:
Identification and characterization of rare antigen-specific T-cell populations.
Research into HLA cross-reactivity and MHC-peptide stability.
Development of personalized immunotherapy protocols.
Explore the NY-ESO-1 86-102 Epitope Cluster
Depending on your HLA-restriction of interest, you might also consider:
NY-ESO-1 86-94 (RLLEFYLAM) – Optimized for HLA-A*02:01
NY-ESO-1_LAGE-2 91-101 (YLAMPFATPME) – Optimized for HLA-A*24:02
NY-ESO-1 93-101 (AMPFATPME) – Optimized for HLA-B*07:02
NY-ESO-1 Peptide Pool, human
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Comprehensive Antigen Scan for Complete T-Cell Profiling
The NY-ESO-1 Peptide Pool from peptides&elephants is a high-performance tool designed for the thorough analysis of T-cell responses against Cancer/Testis Antigen 1 (NY-ESO-1).
Unlike focused sub-pools, this comprehensive pool consists of 43 overlapping peptides (15-mers with an 11-amino acid overlap) spanning the entire length of the NY-ESO-1 protein (UniProt ID: P78358). This peptide scan approach ensures that no potential epitope is missed, making it the ideal tool for screening both CD4+ and CD8+ T-cell responses regardless of the donor's HLA type.
The NY-ESO-1 Peptide Pool is optimized for T-cell assays such as ELISpot, ICS and Flow Cytometry.
Why Use a Full Antigen Scan?
The 15-mer overlapping strategy is the most robust method for immunological profiling:
Unbiased Discovery: Identifies all relevant epitopes across the entire protein sequence.
Dual Activation: The 15-amino acid length is ideal for presentation on both MHC Class I and Class II molecules, activating both CD8+ and CD4+ T-cells.
HLA-Independent: Suitable for use with any donor sample, as it covers all possible HLA-restricted motifs.
Applications & Scientific Validation
This peptide pool is a staple in clinical cancer research and immune monitoring. Its efficacy in detecting tumor-specific immune responses has been demonstrated in various high-impact studies.
Featured Research:
Our NY-ESO-1 pool was a key component in studying immune landscapes in gastrointestinal cancers. For a deep dive into the application of this pool in detecting tumor-associated antigens and HLA-I expression, read our detailed article:
👉 Esophagogastric adenocarcinoma: Tumor-associated antigens, immune responses and HLA-I ExpressionMap the full immune response to NY-ESO-1 with our validated NY-ESO-1 Peptide Pool.
NY-ESO-1 Sub Peptide Pool (>95% HPLC)
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The NY-ESO-1 Sub Peptide Pool from peptides&elephants is a specialized collection of 5 highly validated, overlapping peptides derived from the human Cancer/Testis Antigen 1 (NY-ESO-1; UniProt ID: P78358).
While full protein scans provide a broad overview, this Sub Pool focuses on key immunodominant regions, including the reference epitope SLLMWITQC. This high quality peptide pool is the ideal tool for precise T-cell monitoring, TCR-validation, and the development of targeted cancer vaccines.
Included Peptide Sequences
The NY-ESO-1 Sub Peptide Pool covers a diverse range of HLA restrictions, ensuring broad applicability across different donor profiles:
SLLMWITQC: NY-ESO-1 157-165 (HLA-A*02:01)SLLMWITQV: NY-ESO-1 157-165 mutant (HLA-A*02:01) 165VLLMWITQCF: NY-ESO-1 158-166 (HLA-A*24:02)TVSGNILTIR: NY-ESO-1 127-136 (HLA-A*68:01)MPFATPMEA: NY-ESO-1 94-102 (HLA-B*35:01) (HLA-B*51:01)
Key Applications
Antigen-Specific T-Cell Stimulation: Ideal for ELISpot, Intracellular Cytokine Staining (ICS), and flow cytometry assays.
TCR-T Cell Validation: A critical positive control for verifying the specificity and potency of engineered T-cell receptors.
Immune Monitoring: Reliable benchmarking of patient immune responses in clinical trials and vaccination studies.
Epitope Mapping: Focused screening of dominant NY-ESO-1 regions across multiple HLA alleles.
NY-ESO-1_LAGE-2 91-101 (HLA-A*24:02)
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HLA-A*24:02 Restricted Epitope for Cancer Immunotherapy
NY-ESO-1_LAGE-2 91-101 (YLAMPFATPME) is a well-characterized linear peptidic epitope (Epitope ID: 1075852) derived from the human Cancer/Testis Antigen 1 (NY-ESO-1; UniProt: P78358). This undecamer is a key target for studying immune reactivity in HLA-A*24:02 positive populations, a frequent allele in Asian and Caucasian cohorts.
Structural Significance: As an 11-mer, this epitope forms a non-canonical structural conformation within the MHC-I binding pocket, presenting a distinctive three-dimensional topography to the T-cell receptor (TCR).Scientific Validation:
This epitope has been validated in peer-reviewed literature and immunological databases:
Immune Reactivity: Studied in multiple publications and confirmed in 4 independent T-cell assays.
Functional Response: Proven to trigger IFN-gamma release and specific cytotoxicity.
MHC Binding: Documented positive qualitative binding for HLA-A*24:02.
Applications:
Monitoring of antigen-specific CD8+ T-cell responses.
Validation of TCR-T cell therapies and cancer vaccine candidates.
Cytotoxicity assays (CTL assays) for oncology research.
NY-ESO-1_LAGE-2 91-101 is part of an immunodominant cluster. Depending on your HLA-restriction of interest, you might also consider:
NY-ESO-1 86-94 (RLLEFYLAM) – Optimized for HLA-A*02:01
NY-ESO-1 93-101 (AMPFATPME) – Optimized for HLA-B*07:02
NY-ESO-1 94-102 (MPFATPMEA) – Optimized for HLA-B*35:01 & HLA-B*51:01