HIV Gag 433-440 (HLA-A*02:01)

Therapeutic vaccination of chronically infected HIV-1 subjects was evaluated as a means of halting disease progression. A subdominant peptide vaccine containing 15 CTL epitopes and 3 helper T-cell peptides along with an adjuvant was delivered to 18 infected subjects. Using IFN-? EliSpot, 9 new T-cell responses were detected in 6/14 subjects whose viral loads (VL) remained stable. 7/10 CTL and other pre-existing responses, however, were not significantly detected. Gag433, FLGKIWPS, is a CTL epitope sequence used as a vaccine component.

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