BCR-ABL 926-934 (HLA-A*02:01)
( SSKALQRPV )

In chronic myelogenous leukemia, a translocation occurs between chromosomes 9 and 22, which leads to a BCR-ABL fusion gene. This results in chimeric proteins.

The nonapeptide BCR-ABL 926-934 (epitope ID 2187155) with the amino acid sequence SSKALQRPV from the junctional region of the BCR-ABLb3a2 molecule has been shown to be immunogenic. It could therefore be useful for developing a specific immunotherapy for patients with chronic myelogenous leukemia.
BCR-ABL 926-934 binds to HLA-A2.1 molecules and triggers primary reactions of cytotoxic T lymphocytes in vitro.

Sequence:	SSKALQRPV
Gene:	BCR
Delivery:	3 weeks
C-Terminus:	OH
N-Terminus:	H
Amount:	1 mg
Counter Ion:	TFA
Protein:	Human Bcr-abl 210 kD fusion protein
Species:	Human
Allele:	HLA-A*02:01
Application :	Flow Cytometry
Indication :	Cancer
Purity :	95% HPLC-MS

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Yotnda, P et al. “Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia.” The Journal of clinical investigation vol. 101,10 (1998): 2290-6. doi:10.1172/JCI488

€63.50*

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Available, delivery time: 3-4 weeks

sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity: 95% HPLC-MS

Amount in mg

1 mg

5 mg

Product number: EP12190_1

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