BCR/ABL 210 kD fusion protein 21-29 (HLA-A*03:01) KQSSKALQR

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Tumor Antigen-derived Peptide. GFKQSSKAL is a linear peptidic epitope (epitope ID19558) studied as part of Other Homo sapiens (human) protein from Homo sapiens (human), tested in MHC ligand assayTumor Antigen-derived Peptide. GFKQSSKAL is a linear peptidic epitope (epitope ID19558) studied as part of Other Homo sapiens (human) protein from Homo sapiens (human), tested in MHC ligand assayTumor Antigen-derived Peptide. GFKQSSKAL is a linear peptidic epitope (epitope ID19558) studied as part of Other Homo sapiens (human) protein from Homo sapiens (human), tested in MHC ligand assayTumor Antigen-derived Peptide. GFKQSSKAL is a linear peptidic epitope (epitope ID19558) studied as part of Other Homo sapiens (human) protein from Homo sapiens (human), tested in MHC ligand assayTumor Antigen-derived Peptide. GFKQSSKAL is a linear peptidic epitope (epitope ID19558) studied as part of Other Homo sapiens (human) protein from Homo sapiens (human), tested in MHC ligand assayTumor Antigen-derived Peptide. GFKQSSKAL is a linear peptidic epitope (epitope ID19558) studied as part of Other Homo sapiens (human) protein from Homo sapiens (human), tested in MHC ligand assayTumor Antigen-derived Peptide. GFKQSSKAL is a linear peptidic epitope (epitope ID19558) studied as part of Other Homo sapiens (human) protein from Homo sapiens (human), tested in MHC ligand assay

In chronic myelogenous leukemia, a translocation occurs between chromosomes 9 and 22, which leads to a BCR-ABL fusion gene. This results in chimeric proteins.The nonapeptide BCR-ABL 926-934 (epitope ID 2187155) with the amino acid sequence SSKALQRPV from the junctional region of the BCR-ABLb3a2 molecule has been shown to be immunogenic. It could therefore be useful for developing a specific immunotherapy for patients with chronic myelogenous leukemia. BCR-ABL 926-934 binds to HLA-A2.1 molecules and triggers primary reactions of cytotoxic T lymphocytes in vitro. 

This peptide has high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide composed BCR-ABL 210 kD fusion protein-derived peptide of ATGFKQSSK sequence covering 259-269 and A*03:01, A*11:01 molecule.