We provide the following key modifications:

Phosphorylation:
Addition of phosphate groups to serine, threonine, or tyrosine residues, crucial for studying cellular signaling pathways. 

Acetylation:
N-terminal or lysine acetylation to increase peptide stability and mimic its natural structure in proteins. 

Labeling:
Addition of Biotin, DOTA or fluorescent dyes like FITC, TAMRA etc. The affinity tag biotin can also be used to separate biotinylated peptides. 

PEGylation:
Attachment of polyethylene glycol (PEG) chains to enhance stability and bioavailability of peptides. 

Spacer attachment:
Incorporation of spacers of different lengths into the peptide. 

Oxidation:
Introduction of disulfide bridges for structural stabilization or oxidation of methionine residues. 

Amidation:
C-terminal amidation to neutralize the charge and increase peptide stability. 

Methylation:
Addition of methyl groups to lysine or arginine residues to study epigenetic regulation and protein-protein interactions. 

Palmitoylation: 
S-palmitoylation of cysteine residues and palmitoylation of serine and threonine to enhance membrane association and signaling. 

Sulfation:
Addition of sulfate groups to tyrosine residues, important for many biological processes including receptor-ligand interactions.

Full Conversions: 

• Arginine to Citrulline: Important for studying protein deimination and autoimmune diseases. 
• Glutamic Acid to Pyro-glutamine: Enhances stability and alters peptide function. 

Cyclisation:
Creating cyclic peptides via disulfide bridges, head to tail cyclization or side chain cyclization to enforce defined structures and increase stability. 

Incorporation of Non-Natural Building Blocks: 

• D-Amino Acids, N-methyl amino acids: To increase resistance to enzymatic degradation and modify peptide activity. 
• Organic Molecules: For enhanced functionality and specific interactions. 

Our custom synthesis service allows for these modifications to be precisely integrated into your peptide sequences. Specify your desired modifications in the order form, and our team will ensure they are meticulously incorporated into your peptides to support your research goals.