EBV BRLF1 134-142 (HLA-A*11:01) ATIGTAMYK

The EBV BRLF-1 148–156 peptide (RVRAYTYSK) is a well-characterized CD8+ T-cell epitope derived from the Replication and Transcription Activator (RTA / BRLF-1; UniProt: P03209; epitope ID: 56390) of Epstein-Barr Virus (EBV / Human Herpesvirus 4). As an immediate-early lytic cycle protein, BRLF-1 triggers the viral reactivation cascade, making this nonamer peptide a primary target for assessing lytic-phase CD8+ T-cell responses. Restricted by HLA-A*03:01 and HLA-A*11:01, RVRAYTYSK is an essential component in standardized recall panels and routine human T-cell immunomonitoring.Key Features & BenefitsHLA-A*03:01 & HLA-A*11:01 Restriction: Specific anchor nonamer optimized for precise CD8+ T-cell activation and TCR profiling in HLA-A*03:01- and HLA-A*11:01-positive cohorts.Extensively Validated Benchmark: Backed by 18 peer-reviewed publications and validated across 23 T-cell assays and 2 MHC ligand binding studies worldwide.Core Lytic Control Component: Included as a key reference constituent in peptides&elephants' EBV Control Peptide Pool, CEF (Classic) Peptide Pool, and CEF (Advanced) Peptide Pool (>95% HPLC purity).ApplicationsEBV Lytic Phase Immunomonitoring: Measures functional cytotoxic CD8+ T-cell memory (IFN-gamma, TNF-alpha, CD107a) against immediate-early EBV reactivation in PBMCs.Recall Controls & Assay Standardization: Serves as a reliable positive control in ELISpot, Fluorospot, and Intracellular Cytokine Staining (ICS) assays.MHC Multimer & Tetramer Staining: Ideal reference ligand for generating HLA-A*03:01 and  HLA-A*11:01 peptide-MHC complexes to quantify virus-specific T-cell populations.

#

The EBV BRLF-1 28–37 peptide (DYCNVLNKEF; epitope ID: 10856) is a well-characterized CD8+ T-cell epitope derived from the Replication and Transcription Activator (RTA / BRLF-1; UniProt: P03209) of Epstein-Barr Virus (EBV / Human Herpesvirus 4).As an immediate-early lytic cycle protein, BRLF-1 triggers viral reactivation, making this decamer sequence an essential target for detecting early cytotoxic T-lymphocyte responses. Featuring the amino acid sequence DYCNVLNKEF, this peptide is presented via HLA-A*24:02—an allele highly prevalent in East Asian populations as well as Caucasian cohorts—providing critical coverage for global immune-profiling assays.Key Features & BenefitsHLA-A*24:02 Restriction: High-affinity anchor decamer optimized for precise CD8+ cytotoxic T-cell activation, tetramer generation, and TCR profiling in HLA-A*24:02-positive cohorts.Extensively Validated Target: Backed by a solid evidence base of 12 peer-reviewed publications, 15 functional T-cell assays, and MHC ligand binding studies.Core Control Component: Integrated as an essential reference constituent in peptides&elephants' CEF (Advanced) Peptide Pool (>95% HPLC), CEF (Classic) Peptide Pool (>95% HPLC), and EBV Control Peptide Pool (>95% HPLC).High Chemical Quality: Manufactured by peptides&elephants under strict quality control standards to guarantee high batch-to-batch reproducibility, exceptional solubility, and reliable assay performance.ApplicationsEBV Lytic Phase Immunomonitoring: Measures functional CD8+ Effector and Effector Memory T-cell activation (IFN-gamma, TNF-alpha, CD107a) against immediate-early EBV reactivation in human PBMCs.Recall Controls & Assay Standardization: Serves as a positive control in ELISpot, Fluorospot, and Intracellular Cytokine Staining (ICS) assays.MHC Multimer & Tetramer Staining: Ideal reference ligand for folding HLA-A*24:02 peptide-MHC complexes to isolate and enumerate antigen-specific CD8+ T cells.