Structure of HPV16/18 E6 31-38 (HLA-B*40:02)

Infectious disease

HPV16/18 E6 31-38 (HLA-B*40:02) HDIILECV

Product number: EP14315_1

€105.00*

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Available, delivery time: 3 weeks

sterile and endotoxin free

Delivery Format: The product is supplied freeze dried.

Purity: 95% HPLC-MS

Caution: For research use only. Not for use in humans.

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Description

HDIILECV is a short linear epitope (ID: 110624) mapped to the E6 proteins of Human papillomavirus type 16 and type 18, corresponding to amino acids 31 through 38 of the viral oncoprotein. The E6 sequences referenced are from UniProt entries P03126 (HPV-16) and P06463 (HPV-18), representing the species groups Alphapapillomavirus 9 and Alphapapillomavirus 7, respectively.

E6 facilitates oncogenesis by destabilizing tumor suppressor proteins enabling infected cells to evade normal growth control mechanisms.

Due to its conserved sequence and immunological relevance, the HDIILECV epitope has been analyzed in studies exploring HPV-specific immune responses, particularly in the context of vaccine development and T cell-mediated recognition of infected or transformed cells.

TechData

Sequence:	HDIILECV
Gene:	E6
Delivery:	3 weeks
C-Terminus:	OH
N-Terminus:	H
Amount:	1 mg
Counterion:	TFA
Protein:	Protein E6
UniProt Id:	P03126
Species:	HPV 16, HPV 18
Allele:	HLA-B*40:02
Application:	Flow Cytometry
Indication:	Infectious disease, Cancer
Purity:	95% HPLC-MS

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Storage and handling of peptides

Probing of membranes with HRP

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HNIRGRWTGR is a linear peptide epitope (ID: 110285) originating from the E6 oncoproteins of Human papillomavirus type 16 (UniProt: P03126) and type 18 (UniProt: P06463). It corresponds to amino acids 133 to 142 of the E6 protein sequence and has been investigated for its immunogenic properties, including its recognition by T cells in functional immune assays. HPV-16 and HPV-18 belong to different species groups within the Alphapapillomavirus genus — HPV-16 is part of Alphapapillomavirus 9, while HPV-18 belongs to Alphapapillomavirus 7. Both are considered high-risk oncogenic types, with HPV-16 being the most prevalent and HPV-18 the second most common type found in cervical cancers. The E6 protein is crucial to the virus’s ability to interfere with host cell regulation. It contributes to cancer development by targeting and degrading tumor suppressor proteins, thereby undermining normal cell cycle control and promoting uncontrolled cell proliferation. The E6 region containing this epitope is particularly relevant for immune-based studies due to its potential to elicit virus-specific T cell responses.

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HPV16/18 E6 31-38 (HLA-B*40:02) HDIILECV

€105.00*

Description

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Documents