HPV16/18 E6 133–142 (HLA-A*68:01) HNIRGRWTGR
€210.00*
Description
HNIRGRWTGR is a linear peptide epitope (ID: 110285) originating from the E6 oncoproteins of Human papillomavirus type 16 (UniProt: P03126) and type 18 (UniProt: P06463). It corresponds to amino acids 133 to 142 of the E6 protein sequence and has been investigated for its immunogenic properties, including its recognition by T cells in functional immune assays.
HPV-16 and HPV-18 belong to different species groups within the Alphapapillomavirus genus — HPV-16 is part of Alphapapillomavirus 9, while HPV-18 belongs to Alphapapillomavirus 7. Both are considered high-risk oncogenic types, with HPV-16 being the most prevalent and HPV-18 the second most common type found in cervical cancers.
The E6 protein is crucial to the virus’s ability to interfere with host cell regulation. It contributes to cancer development by targeting and degrading tumor suppressor proteins, thereby undermining normal cell cycle control and promoting uncontrolled cell proliferation. The E6 region containing this epitope is particularly relevant for immune-based studies due to its potential to elicit virus-specific T cell responses.
TechData
| Sequence: | HNIRGRWTGR |
| Gene: | E6 |
| Delivery: | 1-3 days |
| C-Terminus: | OH |
| N-Terminus: | H |
| Amount: | 5 mg |
| Counterion: | TFA |
| Protein: | Protein E6 |
| Species: | HPV 16, HPV 18 |
| Allele: | HLA-A*68:01 |
| Application: | Flow Cytometry |
| Indication: | Infectious disease, Cancer |
| Purity: | 95% HPLC-MS |
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