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Peptide Blog by peptides & elephants

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Peptide Alarm Therapy: A Novel Approach to overcome Immunosuppressive Tumor Microenvironments
December 11, 2024   Dr. Lilian Schoefer
Research updates   cytomegalovirus, t-cell, cancer
An immunosuppressive tumor microenvironment is a major challenge for existing immunotherapies. A novel form of immunotherapy, known as peptide alarm therapy, has shown promise in activating the immune system within tumors by injecting viral peptides.
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Infographic of Peptide Alarm Therapy: Viral peptides label tumor cells for destruction by pre-existing memory T-cells.

FACS analysis showed: CMV-specific T cells respond to leukemia antigen
November 18, 2023   Dr. Lilian Schoefer
Research updates   FACS analysis, myeloid leukemia, cytomegalovirus, CMV
Using FACS analysis and peptide pools from peptides&elephants, they tested whether reactivation of the cytomegalovirus influences T cell immunity against Wilms tumor 1 - and thus against leukemia cells.
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Chart of CMV-specific T-cells stimulated by different antigens
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