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- Order number: EP09863_1
Myelin oligodendrocyte glycoprotein (MOG) 35-53, a minor component of CNS myelin, is expressed... more
Product information "MOG 35 - 53"
Myelin oligodendrocyte glycoprotein (MOG) 35-53, a minor component of CNS myelin, is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 35-53 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. This Cysteine containing MOG (35-53) peptide can be use to induced polyclonal anti-MOG(35-53) antibody production in rabbits with high specificity, high affinity, and high titer indicating its high purity, as well as suitability for peptide-coated ELISA and Western blot assay. Immunization with MOG (35-53) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.
|Protein:||Myelin oligodendrocyte glycoprotein|
|Application :||Multiple Sclerosis|
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