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Des-Leu-kinetensin or histamine-releasing peptide (HRP); was originally isolated from incubates of mammalian albumins with acid proteases; but is also generated by stimulated rat mast cells in the presence of BSA. HRP is able to release histamine from isolated mast cells and to increase cutaneous vascular permeability.  Des-Leu-kinetensin or histamine-releasing peptide (HRP) is chemotactic to human and rat neutrophils.

Angiotensin III (AT III) is the smallest, least active peptide fragment of precursor angiotensinogen. AT III is produced by the degradation of AT II by angiotensinase. AT III has 40% of the vasoconstrictive pressor activity of AT II but increases aldosterone secretion and mean arterial pressure through activity at the AT II type 1 (AT1) receptor.

[Leu31,Pro34]-Neuropeptide Y is a highly potent an selective ligand for the Y1 receptor. High affinity neuropeptide Y Y₁ receptor agonist (K_i = 0.54 nM). Also shows affinity for Y₅ receptors.

B1 bradykinin receptor antagonist.

Bradykinins (BK) and related kinins are potent inflammatory mediators produced during acute and chronic inflammation. The two main ‘kinins’ in mammals are the nonapeptide bradykinin, BK (1-9) and the decapeptide kallidin (KD), [Lys0]-BK(1-10). Their biological actions are mediated by two distinct receptors, termed B1 and B2. BK and [Lys0]-BK are peptides which are released at high nanomolar concentrations into the tear-film of ocular allergic patients.

Human, Bovine, Mouse [Lys1015, 1024]-Thrombospondin-1 (1015-1024) peptide

An inhibitor for Calmodulin-dependent Protein Kinase

Lys8,Asn9]-Neurotensin (8-13) is a neurotensin related hexapeptide from chicken intestine

[Met2]-Deltorphin: The amino acid sequence of the prodermorphin precursor revealed, besides dermorphin, the existence of another peptide distantly related to dermorphin. This peptide was originally proposed as the predicted prodermorphin heptapeptide

For cellular and molecular biology applications

The scrambled peptide [Phe1; Ser2]-TRAP-6 (FSLLRN) may serve as an inactive control for TRAP-6; SFLLRN.

As neuropeptide Y (NPY) and other peptides of its family, [Pro34]-NPY, human, rat peptide adopts a folded hairpin structure with the terminal segments in close proximity. An intracerebroventricular injection of NPY or [Leu31, Pro34]-NPY (non-Y2 receptor agonist) given during middle cerebral artery occlusion increases the infarct volume and nitric oxide (NO) overproduction in the rat brain.

[Pro7]-Neurokinin B is a potent NK-3 receptor agonist

This peptide is a pseudosubstrate for a number of serine/threonine kinases, including protein kinase A (PKA), protein kinase B (PKB), protein kinase C (PKC), protein kinase CHK1, and glycogen synthase kinase 3 (GSK3) different isoforms. The peptide sequence is derived from the residues 19-31 of human protein kinase C isoforms alpha and beta, which contains the R-X-X-S/T consensus motif for Ser/Thr kinases that phosphorylate the Ser25 within this peptide.

[Trp4]-Kemptide is a substrate for adenosine 3',5'-cyclic monophosphate-dependent protein kinase.  Phosphorylation causes a 20% increase in the fluorescence of the peptide

Cardiac natriuretic peptides: hormones with anticancer effects that localize to nucleus, cytoplasm, endothelium, and fibroblasts of human cancers.

• Human Urocortin II, a Selective Agonist for the Type 2 Corticotropin-Releasing Factor Receptor, Decreases Feeding and Drinking in the Rat.
• Urocortin III is expressed in pancreatic beta-cells and stimulates insulin and glucagon secretion.
• Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat.
• Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: role of CRF receptor subtypes 1 and 2.
• Human urocortin II, a new CRF-related peptide, displays selective CRF(2)-mediated action on gastric transit in rats.
• Urocortin reduces oxygen consumption in lean and ob/ob mice.
• Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice.

Other Name: [Tyr1]-pTH (1-34), human

Other Name: [Tyr22]-alpha-Calcitonin Gene Related Peptide (22-37), canine, mouse, rat

Other Name: [Tyr27]-pTH (27-48), human

Other Name:[Tyr36]-Parathyroid Hormone-Related Protein (1-36), human, rat; [Tyr36]-pTH-RP (1-36), human, rat

other name:[Tyr52]-Parathyroid Hormone (52-84), human

[Tyr65,Phe67]-C5a (65-74) is an analog of the human C5a anaphylatoxin C-terminal region. It acts as a full agonist of natural C5a in its ability to induce shape change (polarization) and the release of β-glucuronidase from human neutrophils (PMNs).

Bradykinin is a peptide that exhibits natriuretic, antioxidative, vasodilatory, and pro-angiogenic activities. Bradykinin stimulates bradykinin receptors and increases PLC activity, decreasing ENaC open probability, inhibiting distal nephron Na+ transport, and inducing natriuresis. In vitro, bradykinin decreases H2O2-induced senescence, increases activity of superoxide dismutase (SOD), and suppresses DNA damage, ROS production, and NADPH oxidase activity. Additionally, bradykinin increases expression of VEGF and promotes tube formation in prostate cancer cells.

β-secretase substrate corresponding to the Met/Val substitution of the amyloid precursor protein (APP) β-secretase cleavage site

This is a 26-amino acid neuropeptide belonging to the RFamide family.  It is expressed in the hypothalmus and has orexigenic properties, suggesting it may have a role in controlling feeding behavior.  It may also play a potential role in the control of the gonadotropic axis.

This peptide represents a sequence of triple DYKDDDDK epitopes that is used in studying the function and structure of proteins. It has an increased sensitivity to the anti- DYKDDDDK M2 antibody and can be detected at lower abundance than the octomeric DYKDDDDK tag. A FLAG-tag can be used in many different assays that require recognition by an antibody. If there is no antibody against a given protein, adding a FLAG-tag to a protein allows the protein to be studied with an antibody against the FLAG sequence.

sterile and endotoxin free

4A/4B is a Hepatitus C Virus related peptide.

ILDDIGHGV is a linear peptidic epitope (epitope ID 156689) studied as part of Abl interactor 2 (UniProt:Q9NYB9) from Homo sapiens (human) and Abl interactor 2 (UniProt:E7EW77) from Homo sapiens (human). This epitope has been studied for immune reactivity and was tested in MHC ligand assays

A peptide used to identify the effects of agonists and antagonists on the conformation of estrogen receptors.

Abltide is a peptide substrate for Abl Kinase (Abl protein tyrosine kinase), a partner in the gag-Abl fusion protein of the Abelson murine leukemia virus. Used in Western blot and kinase assay.

Ac-[Asn30,Tyr32]-Calcitonin (8-32), salmon I is a potent and selective antagonist of amylin-induced hyperglycaemia and hyperlactaemia. It has been used to demonstrate that amylin receptors mediate the anorectic action of salmon calcitonin.

Ac-[Leu28,31]-Neuropeptide Y (24-36) is a selective NPY Y2 receptor agonist.

other name: Ac-[Leu28,31]-NPY (24-36)

sterile and endotoxin free

other name: N-Acetyl-ACTH (1-17), human

sterile and endotoxin free

Acetyl-Amylin (8-37), human, completely reversed the inhibitory effects of amylin on 14C-glycogen accumulation in vitro.  It is an effective amylin antagonist with limited ability to block inhibition by CGRP.

sterile and endotoxin free

Application key: E- ELISA, WB- Western blot, IH- Immunohistochemistry, IF- Immunofluorescence, FC- Flow cytometry, IC- Immunocytochemistry, IP- Immunoprecipitation, ChIP- Chromatin Immunoprecipitation, EMSA- Electrophoretic Mobility Shift Assay, BL- Blocking, SE- Sandwich ELISA, CBE- Cell-based ELISA, RNAi- RNA interference

Species reactivity key: H- Human, M- Mouse, R- Rat, B- Bovine, C- Chicken, D- Dog, G- Goat, Mk- Monkey, P- Pig, Rb- Rabbit, S- Sheep, Z- Zebrafish

sterile and endotoxin free

A 27-membered polypeptide comprising the sequence Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2. An acetylated synthetic peptide from human calpastatin that strongly inhibits both calpains I and II but not papain (a cysteine protease) or trypsin (a serine protease).

other name: CALPASTATIN PEPTIDE;CS PEPTIDE HUMAN;CS PEPTIDE;ACETYL-CALPASTATIN (184-210) (HUMAN);ACETYL-CALPASTATIN HUMAN;ACETYL-CALPAIN INHIBITOR FRAGMENT (184-210) (HUMAN);ACETYL-SPERM BS-17 COMPONENT (184-210) (HUMAN);AC-CALPASTATIN (184-210) (HUMAN)

sterile and endotoxin free