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Des-Leu-kinetensin or histamine-releasing peptide (HRP); was originally isolated from incubates of mammalian albumins with acid proteases; but is also generated by stimulated rat mast cells in the presence of BSA. HRP is able to release histamine from isolated mast cells and to increase cutaneous vascular permeability.  Des-Leu-kinetensin or histamine-releasing peptide (HRP) is chemotactic to human and rat neutrophils.

Angiotensin III (AT III) is the smallest, least active peptide fragment of precursor angiotensinogen. AT III is produced by the degradation of AT II by angiotensinase. AT III has 40% of the vasoconstrictive pressor activity of AT II but increases aldosterone secretion and mean arterial pressure through activity at the AT II type 1 (AT1) receptor.

[Leu31,Pro34]-Neuropeptide Y is a highly potent an selective ligand for the Y1 receptor. High affinity neuropeptide Y Y₁ receptor agonist (K_i = 0.54 nM). Also shows affinity for Y₅ receptors.

B1 bradykinin receptor antagonist.

Bradykinins (BK) and related kinins are potent inflammatory mediators produced during acute and chronic inflammation. The two main ‘kinins’ in mammals are the nonapeptide bradykinin, BK (1-9) and the decapeptide kallidin (KD), [Lys0]-BK(1-10). Their biological actions are mediated by two distinct receptors, termed B1 and B2. BK and [Lys0]-BK are peptides which are released at high nanomolar concentrations into the tear-film of ocular allergic patients.

Human, Bovine, Mouse [Lys1015, 1024]-Thrombospondin-1 (1015-1024) peptide

An inhibitor for Calmodulin-dependent Protein Kinase

Lys8,Asn9]-Neurotensin (8-13) is a neurotensin related hexapeptide from chicken intestine

[Met2]-Deltorphin: The amino acid sequence of the prodermorphin precursor revealed, besides dermorphin, the existence of another peptide distantly related to dermorphin. This peptide was originally proposed as the predicted prodermorphin heptapeptide

For cellular and molecular biology applications

The scrambled peptide [Phe1; Ser2]-TRAP-6 (FSLLRN) may serve as an inactive control for TRAP-6; SFLLRN.

As neuropeptide Y (NPY) and other peptides of its family, [Pro34]-NPY, human, rat peptide adopts a folded hairpin structure with the terminal segments in close proximity. An intracerebroventricular injection of NPY or [Leu31, Pro34]-NPY (non-Y2 receptor agonist) given during middle cerebral artery occlusion increases the infarct volume and nitric oxide (NO) overproduction in the rat brain.

[Pro7]-Neurokinin B is a potent NK-3 receptor agonist

[Ser25]-PKC (19-36) Substrate is a high affinity Protein Kinase C pseudosubstrate

Other Names: [Thr30]-NPY, human

Trp3,Arg5]-Ghrelin (1-5) stimulates growth hormone secretion after oral or intravenous administration.  Administrated centrally, it increases food intake in non-fasted mice.

(Trp63,Trp64)-C3a (63-77), synthetic superagonist analog of complement 3a, was 12-15 times more active than natural C3a.

Neuromedin K belongs to the tachykinin family and may play an important role in the olfactory, gustatory, visceral, and neuroendocrine processing information. In addition, it is a potent bronchioconstrictor and has neruomodulatory roles in various brain functions.

also called: [Tyr22]-Gastric Inhibitory Peptide (22-42), human

Other Names: [Tyr0]-pTH-Related Protein (1-34), human, rat; [Tyr0]-pTH-RP (1-34), human, rat; [Tyr0]-Hypercalcemia Malignancy Factor (1-34)

Stresscopin & Stresscopin-related Peptide (Urocortin II & III)

• Human Urocortin II, a Selective Agonist for the Type 2 Corticotropin-Releasing Factor Receptor, Decreases Feeding and Drinking in the Rat.
• Urocortin III is expressed in pancreatic beta-cells and stimulates insulin and glucagon secretion.
• Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat.
• Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: role of CRF receptor subtypes 1 and 2.
• Human urocortin II, a new CRF-related peptide, displays selective CRF(2)-mediated action on gastric transit in rats.
• Urocortin reduces oxygen consumption in lean and ob/ob mice.
• Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice.

 
Sequences

[Tyr1]-Adipokinetic Hormone was used to raise an antiserum used in immunohistochemical studies of Locusta migratoria.

Other Name: [Tyr1]-pTH (1-34), rat

[Tyr1]-TRAP-7 is an antagonist to alpha-thrombin

Other Names [Tyr27]-alpha-Calcitonin Gene Related Peptide (27-37), canine, mouse, rat

other name:[Tyr34]-Parathyroid Hormone (7-34) amide, bovine

other name:[Tyr43]-Parathyroid Hormone (43-68), human

other name:[Tyr63]-Parathyroid Hormone (63-84), human

[Tyr69,Ala71,72,Lys74]-C3a (69-77)-peptide is a potent inhibitor of C3a activity.

[Tyr8] Substance P is a neurotransmitter peptide that is distributed in sensory nerve fibers, bone, and bone-related tissue. It is involved in pain signal transmission and modulates the function of inflammatory and immune responses.

The synthetic octapeptide [Asn¹, Val⁵]-Angiotensin II acts as an angiotensin agonist and is involved in water and blood pressure regulation.

Angiotensin II (AT II) is a peptide produced from AT I by angiotensin-converting-enzyme (ACE). AT II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels; this results in contraction and vasoconstriction, increasing blood pressure. AT II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney. Here, AT II increases reabsorption of Na+ and HCO3- and excretion of H+, increasing blood volume and pH and further increasing blood pressure.

This peptide contains the codon 234 mutational product.  Codon 234 is one of three codons with point mutations in Meth A sarcoma p53

This is a 26-amino acid neuropeptide belonging to the RFamide family.  It is expressed in the hypothalmus and has orexigenic properties, suggesting it may have a role in controlling feeding behavior.  It may also play a potential role in the control of the gonadotropic axis.

This neuropeptide; named 26Rfa; belongs to the RFamide peptide family. The primary structures of human; rat; and frog 26Rfa exhibit 80% identity; and the C-terminal octapeptide is fully conserved from amphibians to mammals. 

4A/4B, 5A/5B Peptide incorporates the P region of the NS4A/4B cleavage site and the P' region of the NS5A/5B from hepatitus C virus.

4B/5A peptide is a hepatitus C virus related peptide.

ILDDIGHGV is a linear peptidic epitope (epitope ID 156689) studied as part of Abl interactor 2 (UniProt:Q9NYB9) from Homo sapiens (human) and Abl interactor 2 (UniProt:E7EW77) from Homo sapiens (human). This epitope has been studied for immune reactivity and was tested in MHC ligand assays

A peptide used to identify the effects of agonists and antagonists on the conformation of estrogen receptors.

Abltide is a peptide substrate for Abl Kinase (Abl protein tyrosine kinase), a partner in the gag-Abl fusion protein of the Abelson murine leukemia virus. Used in Western blot and kinase assay.

Ac-[Asn30,Tyr32]-Calcitonin (8-32), salmon I is a potent and selective antagonist of amylin-induced hyperglycaemia and hyperlactaemia. It has been used to demonstrate that amylin receptors mediate the anorectic action of salmon calcitonin.

Ac-[Leu28,31]-Neuropeptide Y (24-36) is a selective NPY Y2 receptor agonist.

other name: Ac-[Leu28,31]-NPY (24-36)

sterile and endotoxin free

other name: N-Acetyl-ACTH (1-17), human

sterile and endotoxin free

Acetyl-Amylin (8-37), human, completely reversed the inhibitory effects of amylin on 14C-glycogen accumulation in vitro.  It is an effective amylin antagonist with limited ability to block inhibition by CGRP.

sterile and endotoxin free

Application key: E- ELISA, WB- Western blot, IH- Immunohistochemistry, IF- Immunofluorescence, FC- Flow cytometry, IC- Immunocytochemistry, IP- Immunoprecipitation, ChIP- Chromatin Immunoprecipitation, EMSA- Electrophoretic Mobility Shift Assay, BL- Blocking, SE- Sandwich ELISA, CBE- Cell-based ELISA, RNAi- RNA interference

Species reactivity key: H- Human, M- Mouse, R- Rat, B- Bovine, C- Chicken, D- Dog, G- Goat, Mk- Monkey, P- Pig, Rb- Rabbit, S- Sheep, Z- Zebrafish

sterile and endotoxin free

A 27-membered polypeptide comprising the sequence Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2. An acetylated synthetic peptide from human calpastatin that strongly inhibits both calpains I and II but not papain (a cysteine protease) or trypsin (a serine protease).

other name: CALPASTATIN PEPTIDE;CS PEPTIDE HUMAN;CS PEPTIDE;ACETYL-CALPASTATIN (184-210) (HUMAN);ACETYL-CALPASTATIN HUMAN;ACETYL-CALPAIN INHIBITOR FRAGMENT (184-210) (HUMAN);ACETYL-SPERM BS-17 COMPONENT (184-210) (HUMAN);AC-CALPASTATIN (184-210) (HUMAN)

sterile and endotoxin free

Ac-[DTrp16]-Endothelin-1 (16-21) displays high affinity for the ET-A receptor and inhibits ET-1 stimulated arachidonic acid release in rabbit vascular smooth muscle cells.

sterile and endotoxin free

sterile and endotoxin free

sterile and endotoxin free

This peptide is reported to act as a partial agonist of the nocieptin/orphanin FQ receptor expressed in CHO cells. Also, this peptide acts as a competitive antagonist noc/OFQ-stimulated GTP-gamma (35) S binding in rat brain membranes.  

sterile and endotoxin free

Acetalin 1 has a high affinity for m and k3 opiod receptors.

sterile and endotoxin free

Adrenocorticotropin, stimulates androgen production through melanocortin type 2 receptor. Increases protein synthesis in cell bodies of motor neurons. Stimulates fasciculata/reticularis cells. Active in vivo and in vitro.

other name: Adrenocortictropic Hormone (1-16), human

sterile and endotoxin free

Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland. ACTH is an important component of the hypothalamic-pituitary-adrenal axis as a response to biological stress. ACTH secretion is triggered by the corticotropin-releasing hormone (CRH) released from the hypothalamus, and stimulates the adrenal glands to release corticosteroids such as cortisol. ACTH [1-39] corresponds to full-length ACTH. ACTH [1-24] is conserved across species and is 75% as potent as ACTH. ACTH [1-10] has no ACTH activity but alter blood pressure. ACTH [4-10] has neurological effects.

sterile and endotoxin free