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Cancer

NY-ESO-1 Peptide Pool, human

€237.50*

Prices excl. VAT plus shipping costs
Available, delivery time: 1-3 days
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Caution: For research use only. Not for use in humans.
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Product number: LB01362

Description

Comprehensive Antigen Scan for Complete T-Cell Profiling

The NY-ESO-1 Peptide Pool from peptides&elephants is a high-performance tool designed for the thorough analysis of T-cell responses against Cancer/Testis Antigen 1 (NY-ESO-1).

Unlike focused sub-pools, this comprehensive pool consists of 43 overlapping peptides (15-mers with an 11-amino acid overlap) spanning the entire length of the NY-ESO-1 protein (UniProt ID: P78358). The peptide scan approach ensures that no potential epitope is missed, making it the ideal tool for screening both CD4+ and CD8+ T-cell responses regardless of the donor's HLA type.

The NY-ESO-1 Peptide Pool is optimized for T-cell assays such as ELISpot, ICS and Flow Cytometry.

Why Use a Full Antigen Scan?

The 15-mer overlapping strategy is the most robust method for immunological profiling:

  • Unbiased Discovery: Identifies all relevant epitopes across the entire protein sequence.
  • Dual Activation: The 15-amino acid length is ideal for presentation on both MHC Class I and Class II molecules, activating both CD8+ and CD4+ T-cells.
  • HLA-Independent: Suitable for use with any donor sample, as it covers all possible HLA-restricted motifs.

Applications & Scientific Validation

This peptide pool is a staple in clinical cancer research and immune monitoring. Its efficacy in detecting tumor-specific immune responses has been demonstrated in various high-impact studies.

Featured Research:

Our NY-ESO-1 pool was a key component in studying immune landscapes in gastrointestinal cancers. For a deep dive into the application of this pool in detecting tumor-associated antigens and HLA-I expression, read our detailed article:

👉 Esophagogastric adenocarcinoma: Tumor-associated antigens, immune responses and HLA-I Expression

Map the full immune response to NY-ESO-1 with our validated NY-ESO-1 Peptide Pool.

TechData

Gene: CTAG1A
Delivery: 1-3 days
Counterion: TFA
Length: 180 amino acids
No. Peptides: 43 peptides
Amount/Aliquote: 15 nmol (approx. 25µg)/peptide for stimulation of 2,5 x 108 cells
Solubility: Dissolve in a minimum amount of pure DMSO (40µl) and dilute with water to the desired concentration. Please pay attention that the final concentration of DMSO must be below 1% (v/v) to avoid toxicity in the biological system.
Protein: Cancer/testis antigen 1
UniProt Id: P78358
Species: Human
Application: T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication: Cancer

Documents

Material data sheet Safety data sheet Storage and handling of peptides Probing of membranes with HRP

References

Thelen M, Keller D, Lehmann J, et al.: Immune responses against shared antigens are common in esophago-gastric cancer and can be enhanced using CD40-activated B cells. Journal for ImmunoTherapy of Cancer 2022;10:e005200. doi: 10.1136/jitc-2022-005200
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