Influenza A M1 59-68 Peptide ILGFVFTLTV • HLA-A*02:01

The Influenza A HA 116–131 Peptide (epitope ID 73603) is an extended 16-mer CD4+ T-cell epitope derived from the HA1 subunit of Influenza A Hemagglutinin (H3N2). Binding for this MHC Class II ligand has been experimentally validated for HLA-DRB1*01:01, HLA-DRB1*04:01, and HLA-DRB1*07:01. In canonical UniProt entries such as P03437 for A/Aichi/2/1968 or related H3N2 strains like A/Beijing/32/1992, the sequence YDVPDYASLRSLVASS corresponds to amino acids 116–131 of the precursor protein, which represents residues 98–113 of the mature HA1 chain following signal peptide cleavage.Encompassing the well-known core motif YDVPDYASL, this specific 16-amino-acid sequence has been evaluated in specialized immunological studies (e.g., Gelder et al., 1998) to investigate MHC Class II binding capacity and CD4+ T-cell reactivity. It serves as a targeted peptide for Influenza-specific T-cell assays and epitope characterization.

The Influenza A HA 271–286 Peptide (RGYFKMRTGKSSIMRS, IEDB Epitope ID: 54022) is a highly promiscuous, 16-mer CD4+ T-cell epitope derived from Influenza A Hemagglutinin (UniProt ID: P03437). Characterized by its broad MHC Class II binding spectrum, this linear peptide binds with high affinity to HLA-DQA1*01:02 / DQB1*06:02 as well as HLA-DRB1*10:01 and HLA-DRB1*01:01.Due to its ability to be presented across multiple common HLA class II alleles, this sequence is a key target for studying helper T-cell priming, cross-reactive CD4+ responses, and population-wide immunomonitoring. Depending on whether the numbering scheme includes the precursor signal peptide (HA0) or refers to the processed chain, this sequence is annotated as HA 271–286 or HA 255–270.

The Influenza A HA 306–318 Peptide (PKYVKQNTLKLAT) is one of the most thoroughly characterized promiscuous CD4+ T-cell epitopes in viral immunology. Derived from the HA1 subunit of Influenza A Hemagglutinin (strain A/Aichi/2/1968 H3N2; UniProt: P03437), this 13-mer sequence is a benchmark tool for studying broad MHC Class II restriction, helper T-cell activation, and cross-reactive immunity.PKYVKQNTLKLAT is also annotated as HA 322–334 when including the 16-amino-acid N-terminal signal peptide (HA0 precursor numbering). It is part of a coordinated reference panel alongside the truncated HA 322–333 (12-mer) for fine-tuned MHC Class II studies and Influenza B HA 322–334 for type-specific control assays.Indexed under IEDB Epitope ID 48237, this catalog peptide has been featured in over 130 peer-reviewed publications and structurally validated in multiple Protein Data Bank (PDB) co-crystal structures (e.g., 1DLH, 1FYT, 1HXY). It exhibits exceptionally broad binding across numerous human HLA-DR alleles, making it an ideal reference peptide for population-wide immunomonitoring, ELISPOT controls, and vaccine development assays. Key Features & Applications Highly Promiscuous Class II Target: Binds with high affinity across a broad spectrum of HLA-DR alleles, including HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*11:01, HLA-DRB1*07:01, and HLA-DRB5*01:01. Gold-Standard Reference Epitop: Extensively benchmarked in functional CD4+ T-cell activation assays (ELISPOT, ICS, proliferation) and direct MHC ligand binding studies. Structural Proof: High-resolution 3D crystal structures available in the PDB demonstrate its precise molecular interactions within the MHC Class II binding groove.

The Influenza A HA 322–333 Peptide (PKYVKQNTLKLA) is a 12-mer linear CD4+ T-cell epitope derived from the HA1 subunit of Influenza A Hemagglutinin (strain A/Aichi/2/1968 H3N2; UniProt-ID: P03437). Specifically restricted to HLA-DRA*01:01 / DRB1*01:01 (HLA-DR1), this sequence is utilized in cellular immunology to evaluate CD4+ T-cell reactivity, MHC-peptide binding dynamics, and cross-reactive recall responses against seasonal H3N2 strains. It is indexed under IEDB Epitope ID 48231, and has been validated in peer-reviewed publications across functional T-cell activation assays and direct MHC ligand binding studies. PKYVKQNTLKLA serves as a targeted reference peptide for epitope mapping, immunomonitoring, and the development of T-cell-directed influenza vaccine strategies. Corresponding to HA 306–317 in mature HA1 chain numbering, this 12-mer core sequence represents the C-terminally trimmed variant of the canonical Influenza A HA 306–318 (HA 322–334) epitope—offering a high-affinity HLA-DR1 benchmark that perfectly complements both its parent 13-mer and the lineage-matched Influenza B HA 322–334 reference peptide.

The Influenza A M1 58-66 peptide is a linear peptidic epitope (epitope ID 20354) that has the amino acid sequence GILGFVFTL and is located at positions 58-66 of the Matrix Protein 1 (UniProt: P03485) from Influenza A virus.  The M1 58-66 peptide is highly conserved across many strains of influenza, T cells primed to recognize this peptide can potentially recognize and respond to a variety of influenza infections. This makes the M1 58-66 peptide valuable in vaccine research and in the study of cross-protection against different strains of influenza. This catalog peptide is also available in the following off-the-shelf Control Pools:Influenza A M1 Peptide PoolInfluenza control Peptide Pool (>95% HPLC)CEF control Peptide Pool (>95% HPLC, advanced)CEF (classic) Peptide Pool (>95% HPLC) The Influenza A M1 58-66 peptide is well-known for its role in being presented by HLA-A*02:01 (a class I MHC molecule) to cytotoxic CD8+ T cells. It is a well-characterized epitope, making it an ideal tool for studying how T cells recognize viral peptides and initiate an immune response. It is used as a model antigen to study T cell function, activation, and the mechanics of antigen presentation. Understanding how immune cells recognize and target antigens also helps improve T cell-based therapies for cancer.  The Influenza A M1 58-66 peptide has been tested in T cell assays, B cell assays and MHC ligand assays. It is frequently used as a positive control, especially in ELISPOT and tetramer staining, ensuring that the immune cells are functioning as expected. The M1 58-66 peptide is also a prime example of an immunodominant epitope. In people with the HLA-A*02:01 type, a significant portion of the immune response to influenza focuses on this peptide, making it a key target for understanding immune system priorities in viral infections.See also an example comparison of our prices with the prices of other peptide manufacturers.

Influenza peptide ASNENMETM (H-2 Db) is a single peptide for stimulation of T cells. The peptide from Influenza nucleoprotein is synthesized as it is presented by the MHC class I H-2 Db allele and can be used for targeted in vitro generation and expansion of antigen-specific CD8+ T cells.

CTELKLSDY is a linear peptidic epitope (epitope ID 7136) studied as part of Nucleoprotein (UniProt: P03466) from Influenza A virus. This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays This catalog peptide is also available in the following off-the-shelf Control Pools:Influenza control Peptide Pool (>95% HPLC)CEF control Peptide Pool (>95% HPLC, advanced)CEF (classic) Peptide Pool (>95% HPLC)

VSDGGPNLY is a linear peptidic epitope (epitope ID: 70898) studied as part of RNA-directed RNA polymerase catalytic subunit (UniProt-ID: P03431) from Influenza A virus. This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays.This catalog peptide is also available in the following off-the-shelf Control Pools:Influenza control Peptide Pool (>95% HPLC)CEF control Peptide Pool (>95% HPLC, advanced)CEF (classic) Peptide Pool (>95% HPLC)

The Influenza B HA 322–334 Peptide (PYYTGEHAKAIGN) is a linear, 13-mer CD4+ T-cell epitope derived from the Hemagglutinin protein (UniProt: P03460) of the Influenza B virus. Restricted to HLA-DR1 (MHC Class II), this epitope serves as a validated reference peptide for studying helper T-cell responses and cross-reactive cellular immunity against type B influenza strains. PYYTGEHAKAIGN is indexed under IEDB Epitope ID 50200, and has been characterized in T-cell reactivity and MHC binding assays, making it a reliable tool for epitope profiling, immunological monitoring, and vaccine candidate evaluation. Positioned as the type-B structural analogue to the benchmark Influenza A HA 306–318 (HA 322–334) epitope, this 13-mer peptide enables precise discrimination between Influenza A- and B-specific CD4+ helper T-cell responses; paired with the trimmed Influenza A HA 322–333 core sequence, it forms a complete reference set for differential HA immunomonitoring.

The peptide Influenza NP 218-226 (HLA-A*02:01) with the amino acid sequence AYERMCNIL is a linear peptidic epitope (epitope ID 5757) studied as part of Nucleoprotein (UniProt:P03466) from Influenza A virus.Influenza NP 218-226 (HLA-A*02:01) has been studied for immune reactivity in publications and has been tested in T cell assays and MHC ligand assays.