Influenza MP 58-66 (HLA-A*02:01)
( GILGFVFTL )
The Influenza MP 58-66 peptide is a linear peptidic epitope (epitope ID 20354) that has the amino acid sequence GILGFVFTL and is located at positions 58-66 of the Matrix Protein 1 (UniProt:P03485) from Influenza A virus.
The MP 58-66 peptide is highly conserved across many strains of influenza, T cells primed to recognize this peptide can potentially recognize and respond to a variety of influenza infections. This makes the MP 58-66 peptide valuable in vaccine research and in the study of cross-protection against different strains of influenza.
The Influenza MP 58-66 peptide is well-known for its role in being presented by HLA-A*02:01 (a class I MHC molecule) to cytotoxic CD8+ T cells. It is a well-characterized epitope, making it an ideal tool for studying how T cells recognize viral peptides and initiate an immune response. It is used as a model antigen to study T cell function, activation, and the mechanics of antigen presentation. Understanding how immune cells recognize and target antigens also helps improve T cell-based therapies for cancer.
The Influenza MP 58-66 peptide has been tested in T cell assays, B cell assays and MHC ligand assays. It is frequently used as a positive control, especially in ELISPOT and tetramer staining, ensuring that the immune cells are functioning as expected.
The MP 58-66 peptide is also a prime example of an immunodominant epitope. In people with the HLA-A*02:01 type, a significant portion of the immune response to influenza focuses on this peptide, making it a key target for understanding immune system priorities in viral infections.
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| Sequence: | GILGFVFTL | |
| Gene: | mp | |
| Delivery: | 2-3 days | |
| C-Terminus: | OH | |
| N-Terminus: | H | |
| Amount: | 1 mg | |
| Counter Ion: | TFA | |
| Protein: | Matrix protein | |
| Species: | Influenza Virus | |
| Allele: | HLA-A*02:01 | |
| Application : | T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response | |
| Indication : | Infection, Influenza, Swine Flu, Respiratory infection | |
| Purity : | 95% HPLC-MS |
Protocols and Tips
Data sheets
Safety data sheet poly peptides:Dolton, Garry et al. “More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers.” Immunology vol. 146,1 (2015): 11-22. doi:10.1111/imm.12499
€60.40*
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity: 95% HPLC-MS