Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape. SLLNATAIAV had a significantly positive association with HLA A*02; it was recognized by 23/134 A*02-positive subjects and 9/190 A*02-negative subjects.
HLA class I restricted CD8+ T-cell responses against HIV-1 were analyzed in African patients. Significantly more responses were shown to be HLA-B restricted. Viral load, CD4 count, and thus rate of disease progression were also associated with HLA-B alleles. In addition, the selection pressure imposed on HIV-1 by HLA-B alleles was shown to be substantially greater than by other alleles. This epitope was suggested to be the epitope within a longer reactive peptide based on correspondence with a known epitope in the HIV database. Also, a significantly higher frequency of people in the Durban cohort who reacted with the peptide had this HLA type.HLA class I restricted CD8+ T-cell responses against HIV-1 were analyzed in African patients. Significantly more responses were shown to be HLA-B restricted. Viral load, CD4 count, and thus rate of disease progression were also associated with HLA-B alleles. In addition, the selection pressure imposed on HIV-1 by HLA-B alleles was shown to be substantially greater than by other alleles. This epitope was suggested to be the epitope within a longer reactive peptide based on correspondence with a known epitope in the HIV database. Also, a significantly higher frequency of people in the Durban cohort who reacted with the peptide had this HLA type.HLA class I restricted CD8+ T-cell responses against HIV-1 were analyzed in African patients. Significantly more responses were shown to be HLA-B restricted. Viral load, CD4 count, and thus rate of disease progression were also associated with HLA-B alleles. In addition, the selection pressure imposed on HIV-1 by HLA-B alleles was shown to be substantially greater than by other alleles. This epitope was suggested to be the epitope within a longer reactive peptide based on correspondence with a known epitope in the HIV database. Also, a significantly higher frequency of people in the Durban cohort who reacted with the peptide had this HLA type.HLA class I restricted CD8+ T-cell responses against HIV-1 were analyzed in African patients. Significantly more responses were shown to be HLA-B restricted. Viral load, CD4 count, and thus rate of disease progression were also associated with HLA-B alleles. In addition, the selection pressure imposed on HIV-1 by HLA-B alleles was shown to be substantially greater than by other alleles. This epitope was suggested to be the epitope within a longer reactive peptide based on correspondence with a known epitope in the HIV database. Also, a significantly higher frequency of people in the Durban cohort who reacted with the peptide had this HLA type.HLA class I restricted CD8+ T-cell responses against HIV-1 were analyzed in African patients. Significantly more responses were shown to be HLA-B restricted. Viral load, CD4 count, and thus rate of disease progression were also associated with HLA-B alleles. In addition, the selection pressure imposed on HIV-1 by HLA-B alleles was shown to be substantially greater than by other alleles. This epitope was suggested to be the epitope within a longer reactive peptide based on correspondence with a known epitope in the HIV database. Also, a significantly higher frequency of people in the Durban cohort who reacted with the peptide had this HLA type.
GRAFVTIGK is a linear peptidic epitope (epitope ID302918) studied as part of Envelope glycoprotein gp160 from Human immunodeficiency virus 1, tested in MHC ligand assays
This peptide has a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide composed Env-derived peptide of SFNCRGEFFY sequence covering 382-391 and A*29:02 molecule.
RYLRDQQLL is a linear peptidic epitope (epitope ID56585) studied as part of Envelope glycoprotein gp160 from Human immunodeficiency virus 1. This epitope has been studied for immune reactivity, tested in MHC ligand assays
This peptide has a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide composed Env-derived peptide of YLKDQQLL sequence covering 586-593 and B*08:01 molecule.
NVWATHACV is a linear peptidic epitope (epitope ID126795) studied as part of Envelope glycoprotein gp160 from Human immunodeficiency virus 1, tested in MHC ligand assays
RYLKDQQLL is a linear peptidic epitope (epitope ID56574) studied as part of Envelope glycoprotein gp160 from Human immunodeficiency virus 1. This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays Antigen Peptide HIV Env gp160(585-593) (HLA-A*24:02) RYLKDQQLL for stimulation of antigen-specific T cells in T cell assays such as ELISPOT, ICS, cytotoxity or proliferation assays. Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape. RYLKDQQLL had a significantly positive association with HLA A*23; it was recognized by 6/20 A*23-positive subjects and 20/275 A*23-negative subjects.
The peptide HIV-1 Env 345-359 with the amino acid sequence NKGILVTVNPIASTN is a linear peptidic epitope (epitope ID 44494) studied as part of Genome polyprotein (UniProt:P03314) from Yellow fever virus (Flavivirus febricis).HIV-1 Env 345-359 has been studied for immune reactivity in publications and has been tested in T cell assays, B cell assays and MHC ligand assays.
The peptide HIV-1 Env 57-71 with the amino acid sequence RKVCYNAVLTHVKIN is a linear peptidic epitope (epitope ID 54444) studied as part of Genome polyprotein (UniProt:P03314) from Yellow fever virus (Flavivirus febricis).HIV-1 Env 57-71 has been studied for immune reactivity in publications and has been tested in T cell assays, B cell assays and MHC ligand assays.
IPRRIRQGL is a linear peptidic epitope (epitope ID28049) studied as part of Envelope glycoprotein gp160 from Human immunodeficiency virus 1. This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays
KLTPLCVTL is a linear peptidic epitope (epitope ID32201) studied as part of Envelope glycoprotein gp160 from Human immunodeficiency virus 1. This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays
