Cancer
NY-ESO-1_LAGE-2 91-101 (HLA-A*24:02) YLAMPFATPME
€106.60*
Prices excl. VAT plus shipping
costs
Available, delivery time:
1-3 days
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity:
95% HPLC-MS
Caution:
For research use only. Not for use in humans.
Amount in mg
1
Product number: EP11837_1
Description
HLA-A*24:02 Restricted Epitope for Cancer Immunotherapy
NY-ESO-1_LAGE-2 91-101 (YLAMPFATPME) is a well-characterized linear peptidic epitope (Epitope ID: 1075852) derived from the human Cancer/Testis Antigen 1 (NY-ESO-1; UniProt: P78358). This undecamer is a key target for studying immune reactivity in HLA-A*24:02 positive populations, a frequent allele in Asian and Caucasian cohorts.
Scientific Validation:
This epitope has been validated in peer-reviewed literature and immunological databases:
- Immune Reactivity: Studied in multiple publications and confirmed in 4 independent T-cell assays.
- Functional Response: Proven to trigger IFN-gamma release and specific cytotoxicity.
- MHC Binding: Documented positive qualitative binding for HLA-A*24:02.
Applications:
- Monitoring of antigen-specific CD8+ T-cell responses.
- Validation of TCR-T cell therapies and cancer vaccine candidates.
- Cytotoxicity assays (CTL assays) for oncology research.
NY-ESO-1_LAGE-2 91-101 is part of an immunodominant cluster. Depending on your HLA-restriction of interest, you might also consider:
- NY-ESO-1 86-94 (RLLEFYLAM) – Optimized for HLA-A*02:01
- NY-ESO-1 93-101 (AMPFATPME) – Optimized for HLA-B*07:02
- NY-ESO-1 94-102 (MPFATPMEA) – Optimized for HLA-B*35:01 & HLA-B*51:01
TechData
| Sequence: | YLAMPFATPME |
| Gene: | CTAG1A |
| Delivery: | 1-3 days |
| C-Terminus: | OH |
| N-Terminus: | H |
| Amount: | 1 mg |
| Counterion: | TFA |
| Protein: | Cancer testis antigen, NY-ESO-1 |
| Species: | Human |
| Allele: | HLA-A*24:02 |
| Application: | Flow Cytometry |
| Indication: | Cancer |
| Purity: | 95% HPLC-MS |
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Reported in 6 peer-reviewed publications
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Background on NY-ESO-1 and CTAs
NY-ESO-1 is one of the most immunogenic cancer/testis antigens (CTAs). CTAs are normally expressed only in germ cells of the testis but become aberrantly re-expressed in many cancers, including melanoma, lung, ovarian, and esophageal tumors. Because the testis is an immune-privileged site, the immune system does not develop tolerance to these antigens—making them highly attractive targets for cancer immunotherapy and immune monitoring.
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This peptide is part of an immunodominant cluster. Depending on your HLA-restriction of interest, you might also consider:
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NY-ESO-1 and CTAs
NY-ESO-1 belongs to the family of cancer/testis antigens (CTAs), proteins typically restricted to germ cells of the testis but aberrantly expressed in many tumors, including melanoma, lung, ovarian, and esophageal cancers. Because of this unique expression profile and their strong immunogenicity, CTAs like NY-ESO-1 are widely recognized as prime targets for cancer immunotherapy, immune monitoring, and vaccine development.
NY-ESO-1 epitopes such as AMPFATPME contribute to dissecting CD8⁺ T cell responses and advancing the development of diagnostic assays and adoptive T cell therapies.
T cell epitope cluster
This peptide is part of an immunodominant epitope cluster. Depending on your HLA-restriction of interest, you might also consider:
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The NY-ESO-1 Peptide Pool is optimized for T-cell assays such as ELISpot, ICS and Flow Cytometry.
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