In the last 4 years, p&e have developed the use of ultrasound for solid phase peptide synthesis.
The first fully automated process was set up last year. In MTP format, 96 peptides are produced with full cycle times of a few minutes.
At full capacity USPS® needs 8 minutes per 15AA long peptide.Crude purities of up to 92.2 % are achieved in a parallel ACP test synthesis.
Cavitation: USPS® induces Cavitation by controlled ultrasound frequencies this leads to the collapse of gas bubbles (cavities) in the liquid.
The collapse generates local shock waves or jet streams that induces high local energy and super fast reaction mixing.
Image of a cavitating jet in air, HitosHi Soyama,
Int. Journ. of Peening Science and Technology, Vol. 1, pp. 3–60
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