HCMV UL40 15-23 (HLA-E)
( VMAPRTLIL )
HCMV UL40 15-23 with the amino acid sequence VMAPRTLIL is a linear peptidic epitope (epitope ID 69921) that is an important negative regulator of natural killer cell activity. The HCMV UL40 15-23 peptide is often used as positive control.
HCMV UL40 15-23 is part of the immune evasion strategie of the Human Cytomegalovirus (HCMV). The virus downregulates HLA class Ia molecule expression in order to evade T cell recognition. However, a lack of surface HLA class Ia molecules triggers cytotoxicity of Natural Killer (NK) cells. To counteract this effect, the Cytomegalovirus promotes upregulation of HLA-E and provides the peptide HCMV UL40 15-23 (VMAPRTLIL), which mimics the leader sequence of HLA-Cw03 (VMAPRTLIL). When loaded onto HLA-E, this peptide conferres resistance to NK cell lysis via the CD94/NKG2A receptor.
HLA-E is presenting peptides derived from self-proteomic content and peptides of pathogenic origin. VMAPRTLIL is part of the following proteins of human origin:
- Major histocompatibility complex, class I, C (UniProt:A0A140T9M0, A0A140T9U0, A0A0G2JH50, A0A140T912 and A0A140T9Z4)
- HLA class I histocompatibility antigen C alpha chain (UniProt:Q53YP1, Q5RIP0)
- HLA class I antigen (UniProt:Q5QT33)
- Isoform 2 of HLA class I histocompatibility antigen, C alpha chain (UniProt:P10321-2)
Sequence: | VMAPRTLIL | |
Gene: | UL111A | |
Delivery: | 2-3 days | |
C-Terminus: | OH | |
N-Terminus: | H | |
Amount: | 1 mg | |
Counter Ion: | TFA | |
Protein: | Viral interleukin-10 homolog | |
Species: | HCMV | |
Allele: | HLA-E* | |
Application : | Flow Cytometry | |
Purity : | 95% HPLC-MS |
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Data sheets
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€60.40*
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity: 95% HPLC-MS