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HCMV UL40 15-23 (HLA-E)
( VMAPRTLIL )



HCMV UL40 15-23 with the amino acid sequence VMAPRTLIL is a linear peptidic epitope (epitope ID 69921) that is an important negative regulator of natural killer cell activity. The HCMV UL40 15-23 peptide is often used as positive control.

HCMV UL40 15-23 is part of the immune evasion strategie of the Human Cytomegalovirus (HCMV). The virus downregulates HLA class Ia molecule expression in order to evade T cell recognition. However, a lack of surface HLA class Ia molecules triggers cytotoxicity of Natural Killer (NK) cells. To counteract this effect, the Cytomegalovirus promotes upregulation of HLA-E and provides the peptide HCMV UL40 15-23 (VMAPRTLIL), which mimics the leader sequence of HLA-Cw03 (VMAPRTLIL). When loaded onto HLA-E, this peptide conferres resistance to NK cell lysis via the CD94/NKG2A receptor. 

HLA-E is presenting peptides derived from self-proteomic content and peptides of pathogenic origin. VMAPRTLIL is part of the following proteins of human origin:

  • Major histocompatibility complex, class I, C (UniProt:A0A140T9M0, A0A140T9U0, A0A0G2JH50, A0A140T912 and A0A140T9Z4)
  • HLA class I histocompatibility antigen C alpha chain (UniProt:Q53YP1, Q5RIP0)
  • HLA class I antigen (UniProt:Q5QT33)
  • Isoform 2 of HLA class I histocompatibility antigen, C alpha chain (UniProt:P10321-2)
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Sequence:VMAPRTLIL
Gene:UL111A
Delivery: 2-3 days
C-Terminus:OH
N-Terminus:H
Amount:1 mg
Counter Ion:TFA
Protein:Viral interleukin-10 homolog
Species:HCMV
Allele:HLA-E*
Application :Flow Cytometry
Indication :Infectious disease, Cancer, Neuroscience, Diabetes
Purity :95% HPLC-MS
Vietzen, Hannes et al. “Torque teno viruses exhaust and imprint the human immune system via the HLA-E/NKG2A axis.” Frontiers in immunology vol. 15 1447980. 4 Sep. 2024, doi:10.3389/fimmu.2024.1447980

Martín Almazán, Nerea et al. “Non-classical HLA-E restricted CMV 15-mer peptides are recognized by adaptive NK cells and induce memory responses.” Frontiers in immunology vol. 14 1230718. 21 Sep. 2023, doi:10.3389/fimmu.2023.1230718

€63.50*

Delivery time 2-3 days
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity: 95% HPLC-MS
Amount in mg
Product number: EP06244_1