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Influenza A M1 13-21 (HLA-A11:01)(HLA-A03:01)(HLA-A31:01)(HLA-A68:01)
( SIIPSGPLK )

The Influenza A M1 13–21 epitope (amino acid sequence: SIIPSGPLK) is a well-characterized CD8⁺ T cell epitope derived from the Matrix Protein 1 (M1) of the Influenza A virus (UniProt ID: P03485). This 9-mer linear peptide is located within the membrane-binding domain of M1 and is known to be presented on several HLA class I molecules, including:

HLA-A*11:01
HLA-A*03:01
HLA-A*31:01
HLA-A*68:01

This epitope has been referenced under IEDB Epitope ID: 58567 and has been widely studied in the context of T cell recognition, MHC class I binding, and antiviral immune responses.

Applications:

Detection of Influenza-specific CD8⁺ T cells
HLA-A-restricted antigen presentation analysis
Use in T cell activation assays (e.g., ELISPOT, ICS)
Validation of TCR transgenic systems or HLA tetramer tools
Monitoring immune responses in vaccine or infection models

Epitope Background

This epitope, SIIPSGPLK, is derived from Matrix Protein 1 (M1) of Influenza A virus, a structural protein involved in virion stability, uncoating, and regulation of transcription. The 13–21 region lies within the membrane-binding domain, which interacts with the inner side of the viral lipid bilayer.

Sequence:	SIIPSGPLK
Gene:	M
Delivery:	2-3 days
C-Terminus:	OH
N-Terminus:	H
Amount:	1 mg
Counter Ion:	TFA
Protein:	Matrix protein
Species:	Influenza Virus
Allele:	HLA-A11:01 HLA-A03:01 HLA-A31:01 HLA-A68:01
Application :	T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication :	Infection, Influenza, Swine Flu, Respiratory infection
Purity :	95% HPLC-MS

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€63.50*

Prices excl. VAT plus shipping costs

Delivery time 2-3 days
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity: 95% HPLC-MS

Amount in mg

1 mg

5 mg

Product number: EP11314_1

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Influenza A M1 13-21 (HLA-A*11:01)(HLA-A*03:01)(HLA-A*31:01)(HLA-A*68:01) ( SIIPSGPLK )

The Influenza A M1 13–21 epitope (amino acid sequence: SIIPSGPLK) is a well-characterized CD8⁺ T cell epitope derived from the Matrix Protein 1 (M1) of the Influenza A virus (UniProt ID: P03485). This 9-mer linear peptide is located within the membrane-binding domain of M1 and is known to be presented on several HLA class I molecules, including: HLA-A*11:01 HLA-A*03:01 HLA-A*31:01 HLA-A*68:01 This epitope has been referenced under IEDB Epitope ID: 58567 and has been widely studied in the context of T cell recognition, MHC class I binding, and antiviral immune responses. Applications: Detection of Influenza-specific CD8⁺ T cells HLA-A-restricted antigen presentation analysis Use in T cell activation assays (e.g., ELISPOT, ICS) Validation of TCR transgenic systems or HLA tetramer tools Monitoring immune responses in vaccine or infection models Epitope Background This epitope, SIIPSGPLK, is derived from Matrix Protein 1 (M1) of Influenza A virus, a structural protein involved in virion stability, uncoating, and regulation of transcription. The 13–21 region lies within the membrane-binding domain, which interacts with the inner side of the viral lipid bilayer.

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Influenza A M1 178-187 (HLA-A*11:01) ( RMVLASTTAK )

RMVLASTTAK is a linear peptidic epitope (epitope ID54953) studied as part of Matrix protein 1 from Influenza A virus. This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays

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Influenza A M1 58-66 (HLA-A*02:01) ( GILGFVFTL )

The Influenza A M1 58-66 peptide is a linear peptidic epitope (epitope ID 20354) that has the amino acid sequence GILGFVFTL and is located at positions 58-66 of the Matrix Protein 1 (UniProt:P03485) from Influenza A virus. The M1 58-66 peptide is highly conserved across many strains of influenza, T cells primed to recognize this peptide can potentially recognize and respond to a variety of influenza infections. This makes the M1 58-66 peptide valuable in vaccine research and in the study of cross-protection against different strains of influenza. The Influenza A M1 58-66 peptide is well-known for its role in being presented by HLA-A*02:01 (a class I MHC molecule) to cytotoxic CD8+ T cells. It is a well-characterized epitope, making it an ideal tool for studying how T cells recognize viral peptides and initiate an immune response. It is used as a model antigen to study T cell function, activation, and the mechanics of antigen presentation. Understanding how immune cells recognize and target antigens also helps improve T cell-based therapies for cancer. The Influenza A M1 58-66 peptide has been tested in T cell assays, B cell assays and MHC ligand assays. It is frequently used as a positive control, especially in ELISPOT and tetramer staining, ensuring that the immune cells are functioning as expected. The M1 58-66 peptide is also a prime example of an immunodominant epitope. In people with the HLA-A*02:01 type, a significant portion of the immune response to influenza focuses on this peptide, making it a key target for understanding immune system priorities in viral infections.See also an example comparison of our prices with the prices of other peptide manufacturers.

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Influenza A M1 59-68 (HLA-A*02:01) ( ILGFVFTLTV )

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Influenza A M1 Peptide Pool

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