Influenza A M1 13-21 (HLA-A*11:01)(HLA-A*03:01)(HLA-A*31:01)(HLA-A*68:01)
( SIIPSGPLK )
The Influenza A M1 13–21 epitope (amino acid sequence: SIIPSGPLK) is a well-characterized CD8⁺ T cell epitope derived from the Matrix Protein 1 (M1) of the Influenza A virus (UniProt ID: P03485). This 9-mer linear peptide is located within the membrane-binding domain of M1 and is known to be presented on several HLA class I molecules, including:
- HLA-A*11:01
- HLA-A*03:01
- HLA-A*31:01
- HLA-A*68:01
This epitope has been referenced under IEDB Epitope ID: 58567 and has been widely studied in the context of T cell recognition, MHC class I binding, and antiviral immune responses.
Applications:
- Detection of Influenza-specific CD8⁺ T cells
- HLA-A-restricted antigen presentation analysis
- Use in T cell activation assays (e.g., ELISPOT, ICS)
- Validation of TCR transgenic systems or HLA tetramer tools
- Monitoring immune responses in vaccine or infection models
Epitope Background
This epitope, SIIPSGPLK, is derived from Matrix Protein 1 (M1) of Influenza A virus, a structural protein involved in virion stability, uncoating, and regulation of transcription. The 13–21 region lies within the membrane-binding domain, which interacts with the inner side of the viral lipid bilayer.
Sequence: | SIIPSGPLK | |
Gene: | M | |
Delivery: | 2-3 days | |
C-Terminus: | OH | |
N-Terminus: | H | |
Amount: | 1 mg | |
Counter Ion: | TFA | |
Protein: | Matrix protein | |
Species: | Influenza Virus | |
Allele: | HLA-A*11:01 HLA-A*03:01 HLA-A*31:01 HLA-A*68:01 | |
Application : | T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response | |
Indication : | Infection, Influenza, Swine Flu, Respiratory infection | |
Purity : | 95% HPLC-MS |
Protocols and Tips
Data sheets
Safety data sheet poly peptides:For your convenience, we have compiled a selection of publications
where our peptide products have been employed:
Publications >
€63.50*
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity: 95% HPLC-MS