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Structure of Influenza A HA 332-340 (H-2-Db)
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Infectious disease

Influenza A HA 332-340 (H-2-Db) TGLRNTPSI

Product number: EP12102_1

€ 105.00 *

Prices excl. VAT plus shipping costs
Available, delivery time: 3 weeks
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity: 95% HPLC-MS
Caution: For research use only. Not for use in humans.
Amount in mg
1
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Description

The Influenza A virus 332–340 peptide (TGLRNTPSI, epitope ID: 187544 ) is a murine MHC Class I-restricted CD8+ T-cell epitope derived from the Hemagglutinin glycoprotein (HA; UniProt: P03452) of Influenza A virus. 

Recognized specifically in the context of the murine H-2Db allele, this nonamer sequence represents a key target for studying virus-specific cytotoxic T-lymphocyte (CTL) responses in preclinical mouse models. Featuring the amino acid sequence TGLRNTPSI, this high-quality reference peptide by peptides&elephants is an essential tool for epitope mapping, tetramer staining, and evaluating influenza vaccine candidate efficacy in vivo.

Key Features & Benefits

  • Murine H-2Db Restriction: High-affinity anchor nonamer optimized for precise CD8+ T-cell activation, tetramer generation, and cellular immunomonitoring in H-2Db-matched murine models.
  • Hemagglutinin-Specific Target: Enables targeted profiling of cytotoxic immune responses directed against the primary envelope antigen of Influenza A.
  • Preclinical Benchmark: Evaluated in functional T-cell activation assays and MHC ligand binding studies, establishing its utility in mouse models of viral infection.
  • High Chemical Quality: peptides&elephants strict quality control standards guarantee high batch-to-batch reproducibility, and dependable assay performance.

Applications

  • Murine Immunomonitoring: Quantifies antigen-specific CD8+ T-cell responses (IFN-gamma ELISpot, ICS, proliferation) in splenocytes or lymphocytes from Influenza A-infected or vaccinated mice.
  • Preclinical Vaccine Validation: Serves as a target to benchmark viral vector-, peptide-, or mRNA-based influenza vaccine candidates in C57BL/6 model systems.
  • MHC Class I Multimer Generation: Ideal reference ligand for folding H-2Db monomer/tetramer complexes to stain and isolate antigen-specific murine CD8+ T cells.

TechData

Sequence: TGLRNTPSI
Gene: HA
Delivery: 3 weeks
C-Terminus: OH
N-Terminus: H
Amount: 1 mg
Counterion: TFA
Protein: Hemagglutinin
UniProt Id: P03452
IEDB Id: 187544
Species: Influenza A virus
Allele: H-2Db
Application: T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication: Infectious disease
Purity: 95% HPLC-MS

Documents

Material data sheet Safety data sheet Storage and handling of peptides Probing of membranes with HRP
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