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Infectious disease

EBV (EBNA-3a) Peptide Pool

€301.30*

Prices excl. VAT plus shipping costs
Available, delivery time: 1-3 days
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Caution: For research use only. Not for use in humans.
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Product number: LB01361

Description

The EBV (EBNA-3a) Peptide Pool from peptides&elephants is designed for in vitro T cell stimulation and epitope analysis in research on Epstein-Barr virus (EBV, HHV-4). This pool contains 234 synthetic 15-mer peptides, overlapping by 11 amino acids, and spans the complete sequence of EBNA-3a (Epstein-Barr nuclear antigen 3a; UniProt ID: P12977). Each unit enables the stimulation of up to 2.5 × 10⁸ peripheral blood mononuclear cells (PBMCs) and is ideal for use in ELISpot, intracellular cytokine staining (ICS), and flow cytometry-based T cell assays.

Scientific Background

EBV is a ubiquitous herpesvirus that infects more than 90% of the global population. It is the causative agent of infectious mononucleosis and is closely associated with several B cell malignancies, including post-transplant lymphoproliferative disease (PTLD), diffuse large B cell lymphoma (DLBCL), Burkitt lymphoma, and Hodgkin lymphoma.

During latency, EBV can enter different gene expression programs. Latency type III, in which all nine latent proteins are expressed, is the only form capable of transforming B cells in vitro, resulting in lymphoblastoid cell lines (LCLs). Among these latency proteins, EBNA-3a plays a supportive but non-essential role in B cell transformation:

  • EBV mutants lacking EBNA-3a can still transform B cells, but with significantly reduced efficiency.
  • EBNA-3a–deficient LCLs proliferate more slowly and show increased apoptosis compared to wild-type virus–derived LCLs.
  • EBNA-3a appears to regulate a subset of cellular genes, some of which overlap with those regulated by EBNA2. The two proteins can act antagonistically or cooperatively to control gene expression.

These findings position EBNA-3a as a key modulator of B cell proliferation and survival during EBV latency, and as a relevant CD8⁺ T cell target in both basic immunological studies and translational research.

TechData

Gene: EBNA3
Delivery: 1-3 days
Counterion: TFA
Length: 944 amino acids
No. Peptides: 234 peptides
Amount/Aliquote: 15 nmol (approx. 25µg)/peptide for stimulation of 2,5 x 108 cells
Solubility: Dissolve in a minimum amount of pure DMSO (40µl) and dilute with water to the desired concentration. Please pay attention that the final concentration of DMSO must be below 1% (v/v) to avoid toxicity in the biological system.
Protein: Epstein-Barr nuclear antigen 3
UniProt Id: P12977
Species: Epstein-Barr virus (EBV; Human herpesvirus 4)
Application: T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication: Infectious disease, Cancer, Neuroscience

Documents

Material data sheet Safety data sheet Storage and handling of peptides Probing of membranes with HRP

References

Romero-Masters, James C et al. “An EBNA3A-Mutated Epstein-Barr Virus Retains the Capacity for Lymphomagenesis in a Cord Blood-Humanized Mouse Model.” Journal of virology vol. 94,10 e02168-19. 4 May. 2020, doi:10.1128/JVI.02168-19
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EBNA 3a (596-604)
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EBNA-1 Protein (562-570)
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EBV EBNA 3C 258-266 (HLA-B*27:02)(HLA-B*27:05)(HLA-B*27:04)
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EBV EBNA-1 407-417 (HLA-B*35:01)
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EBV EBNA-3A 458-466 (HLA-B*35:01)
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EBV EBNA2 280-290 (DRB1*01:01)
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EBV EBNA3A 158-166 (HLA-B*08:01)
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EBV EBNA3B 416-424 (HLA-A*11:01; HLA-A*68:01)
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EBV EBNA3C 281-290 (HLA-B*44:05)
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EBNA3C-derived peptide of EENLLDFVRF covering 281-290 and B*44:05 molecule. The EBV EBNA3C 281-290 (HLA-B*44:05) peptide recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. EENLLDFVRF is a linear peptidic epitope (epitope ID11804) studied as part of Epstein-Barr nuclear antigen 6 from Human herpesvirus 4 (Epstein Barr virus). This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays

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EBV EBNA Peptides

EBNA 3a (596-604)
EBNA 3a (596-604)
This peptide represents an HLA-A2-restricted epitope of the Epstein-Barr virus nuclear antigen 3 (EBNA 3). EBNA 3 is a transcriptional regulatory protein that promotes B cell activation through the RBP-Jk pathway. This peptide is used in the study of immunotherapy for solid organ transplant patients.

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EBNA-1 Protein (562-570)
EBNA-1 Protein (562-570)
The Epstein-Barr virus (EBV), also called Human herpes virus 4 (HHV-4), is a virus of the herpes family (which includes Herpes simplex virus and Cytomegalo virus). On infecting the B-lymphocyte, the linear virus genome circularizes and the virus subsequently persists within the cell as an episome. The virus can execute several distinct programs of gene expression which can be broadly categorized as being lytic cycle or latent cycle. The lytic cycle or productive infection results in staged expression of a host of viral proteins with the ultimate objective of producing infectious virions. Formally, this phase of infection does not inevitably lead to lysis of the host cell as EBV virions are produced by budding from the infected cell. The latent cycle (lysogenic) programs are those that do not result in production of virions.

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EBV EBNA 3A 246-253 (HLA-A*24:02)
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EBV EBNA 3B 399-408 (HLA-A*11:01)
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EBV EBNA 3C 258-266 (HLA-B*27:02)(HLA-B*27:05)(HLA-B*27:04)
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EBV EBNA-1 407-417 (HLA-B*35:01)
EBV EBNA-1 407-417 (HLA-B*35:01)
Antigen Peptide EBV EBNA-1 407-417 (HLA-B*35:01) HPVGEADYFEY for stimulation of antigen-specific T cells in T cell assays such as ELISPOT, ICS, cytotoxity or proliferation assays. HPVGEADYFEY for stimulation of human EBV EBNA-1-specific CD8+ T-cells. The peptide is synthesised as it is presented by the MHC class I HLA-B*3501 allele. HPVGEADYFEY is a linear peptidic epitope (epitope ID24536) studied as part of Epstein-Barr nuclear antigen 1 from Human herpesvirus 4 (Epstein Barr virus). This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays.

From €105.00*
Details
EBV EBNA-1 407-417 mutant (HLA-B*35:01) 410A
EBV EBNA-1 407-417 mutant (HLA-B*35:01) 410A
EBNA1-derived peptide of HPVAEADYFEY covering 407-417 and B*35:08 molecule. HPVAEADYFEY is a linear peptidic epitope (epitope ID 227777) studied as part of Epstein-Barr nuclear antigen 1 from Human herpesvirus 4 (Epstein Barr virus). This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays.

From €106.60*
Details
EBV EBNA-1 407-417 mutant (HLA-B*35:08) 411D
EBV EBNA-1 407-417 mutant (HLA-B*35:08) 411D
EBV EBNA1-derived peptide of HPVGDADYFEY covering 407-417 and B*35:08 molecule. HPVGDADYFEY is a linear peptidic epitope (epitope ID 24525) studied as part of Epstein-Barr nuclear antigen 1 from Human herpesvirus 4 (Epstein Barr virus). This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays

From €106.60*
Details
EBV EBNA-1 72-80 (HLA-B*35:01)
EBV EBNA-1 72-80 (HLA-B*35:01)
RPQKRPSCI is a linear peptidic epitope studied as part of Epstein-Barr nuclear antigen 1 from Human herpesvirus 4 (Epstein Barr virus). This epitope has been studied for immune reactivity, tested in T cell assays.

From €105.00*
Details
EBV EBNA-3A 325-333 (HLA-B*08:01)
EBV EBNA-3A 325-333 (HLA-B*08:01)
Antigen Peptide EBV EBNA3A HLA-B*08:01 (FLRGRAYGL) for stimulation of human EBV EBNA-3A(325-333) -specific CD8+ T-cells. The peptide is synthesised as it is presented by the MHC class I HLA-B*0801 allele.

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EBV EBNA-3A 379-387 (HLA-B*07:02)
EBV EBNA-3A 379-387 (HLA-B*07:02)
Antigen Peptide EBV EBNA3A HLA-B*07:02 (RPPIFIRRL) for stimulation of human EBV EBNA-3A (379-387) specific CD8+ T-cells. The peptide is synthesised as it is presented by the MHC class I HLA-B*0702 allele.

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EBV EBNA-3A 458-466 (HLA-B*35:01)
EBV EBNA-3A 458-466 (HLA-B*35:01)
HLA-B35-restricted epitope from Epstein-Barr Virus latent nuclear antigen 3A (458-466) for stimulation of antigen-specific T cells in T cell assays such as ELISPOT, ICS, cytotoxity or proliferation assays.

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EBV EBNA-3A 603-611 (HLA-A*03:01)
EBV EBNA-3A 603-611 (HLA-A*03:01)
RLRAEAQVK is a linear peptidic epitope (epitope ID54728) studied as part of Epstein-Barr nuclear antigen 3 from Human herpesvirus 4 (Epstein Barr virus). This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays

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EBV EBNA-3C 284-293 (HLA-A*02:01)
EBV EBNA-3C 284-293 (HLA-A*02:01)
LLDFVRFMGV is a linear peptidic epitope (epitope ID 37153) studied as part of Epstein-Barr nuclear antigen 6 from Human herpesvirus 4 (Epstein Barr virus) and Other Human herpesvirus 4 (Epstein Barr virus) protein from Human herpesvirus 4 (Epstein Barr virus). This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays

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EBV EBNA-3C 881-889 (HLA-B*07:02)
EBV EBNA-3C 881-889 (HLA-B*07:02)
QPRAPIRPI is a linear peptidic epitope (epitope ID 51946) studied as part of Epstein-Barr nuclear antigen 6 from Human herpesvirus 4 (Epstein Barr virus). This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays

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EBV EBNA2 280-290 (DRB1*01:01)
EBV EBNA2 280-290 (DRB1*01:01)
The peptide EBV EBNA2 280–290 (TVFYNIPPMPL) from peptides&elephants is a synthetic antigenic epitope derived from Epstein–Barr nuclear antigen 2 (EBNA2) of Epstein–Barr virus (Human herpesvirus 4). EBNA2 is a central transcriptional regulator expressed during early stages of EBV infection and plays a crucial role in the establishment of viral latency and the reprogramming of infected B cells.For a deeper understanding of the biological role of EBNA2 in early EBV infection and viral transcriptional control, explore the EBV Peptide Insights section by peptides&elephants.   EBV EBNA2 280–290 corresponds to a linear T-cell epitope (IEDB ID 67007) located within the EBNA2 protein (UniProt ID: P12978). It has been experimentally studied for immune reactivity and evaluated in multiple functional T-cell assays. The epitope is presented in the context of HLA-DRB1*01:01, enabling recognition by CD4⁺ T cells.   Experimental studies have demonstrated positive immune responses in several assay formats, including interferon-γ (IFNγ) release assays, T-cell proliferation assays, and cytotoxicity assays. These findings indicate that the peptide can effectively stimulate EBNA2-specific T-cell responses and is therefore suitable for applications in cellular immunology and EBV research.   Because EBNA2 is a key driver of early transcriptional reprogramming in EBV-infected cells, peptides derived from this protein are valuable tools for studying virus-host interactions, T-cell immunity to EBV, and immune recognition of latency-associated antigens.   Applications Stimulation of EBV-specific T cells ELISpot and FluoroSpot assays Intracellular cytokine staining (ICS) T-cell proliferation assays Cytotoxicity assays Epitope validation and immune monitoring in EBV research

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EBV EBNA3A 158-166 (HLA-B*08:01)
EBV EBNA3A 158-166 (HLA-B*08:01)
QAKWRLQTL is a linear peptidic epitope (epitope ID50298) studied as part of Epstein-Barr nuclear antigen 3 from Human herpesvirus 4 (Epstein Barr virus). This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays

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EBV EBNA3B 416-424 (HLA-A*11:01; HLA-A*68:01)
EBV EBNA3B 416-424 (HLA-A*11:01; HLA-A*68:01)

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EBV EBNA3C 281-290 (HLA-B*44:05)
EBV EBNA3C 281-290 (HLA-B*44:05)
EBNA3C-derived peptide of EENLLDFVRF covering 281-290 and B*44:05 molecule. The EBV EBNA3C 281-290 (HLA-B*44:05) peptide recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. EENLLDFVRF is a linear peptidic epitope (epitope ID11804) studied as part of Epstein-Barr nuclear antigen 6 from Human herpesvirus 4 (Epstein Barr virus). This epitope has been studied for immune reactivity, tested in T cell assays and MHC ligand assays

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