EBV EBNA-3A 603-611 (HLA-A*03:01) RLRAEAQVK
€ 105.00 *
Description
The EBV EBNA-3A 603–611 peptide (RLRAEAQVK) is a widely characterized CD8+ T-cell epitope derived from Epstein-Barr nuclear antigen 3A (EBNA-3A / EBNA-3; UniProt: P12977; epitope ID: 54728) of Epstein-Barr Virus (EBV / Human Herpesvirus 4).
As a vital nuclear protein expressed during latent EBV infection, EBNA-3A is a primary immunotarget for cytotoxic T lymphocytes. Restricted by HLA-A*03:01, this nonamer peptide is a trusted reference tool for assessing latent T-cell memory, performing functional recall assays, and benchmarking antiviral immune responses.
Key Features & Benefits
- HLA-A*03:01 Restriction: High-affinity CD8+ anchor nonamer optimized for precise cytotoxic T-cell stimulation and TCR profiling in HLA-A*03:01-positive cohorts.
- Extensively Validated Target: Supported by 28 peer-reviewed publications and tested across 37 functional T-cell assays and 3 MHC ligand binding studies.
- Core Control Component: Integrated as a key reference constituent in peptides&elephants' EBV (EBNA-3a) Peptide Pool, EBV Control Peptide Pool, CEF (Classic) Peptide Pool, and CEF (Advanced) Peptide Pool (>95% HPLC purity).
Applications
- EBV Latent Phase Immunomonitoring: Quantifies functional CD8+ T-cell memory (IFN-gamma, TNF-alpha, CD107a) directed against latent viral antigens in human PBMCs.
- Positive Control & Assay Validation: Serves as a reliable control in ELISpot, Fluorospot, and Intracellular Cytokine Staining (ICS) assays.
- MHC Multimer & Tetramer Staining: Ideal reference ligand for generating HLA-A*03:01 peptide-MHC complexes to isolate and enumerate antigen-specific CD8+ T cells.
TechData
| Sequence: | RLRAEAQVK |
| Gene: | EBNA |
| Delivery: | 1-3 days |
| C-Terminus: | OH |
| N-Terminus: | H |
| Amount: | 1 mg |
| Counterion: | TFA |
| Protein: | Epstein-Barr nuclear antigen |
| UniProt Id: | P12977 |
| IEDB Id: | 54728 |
| Species: | Epstein-Barr virus (EBV; Human herpesvirus 4) |
| Allele: | HLA-A*03:01 |
| Application: | T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response |
| Indication: | Infectious disease, Cancer, Neuroscience |
| Purity: | 95% HPLC-MS |
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