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Structure of EBV EBNA3B 416-424 (HLA-A*11:01; HLA-A*68:01)
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Infectious disease

EBV EBNA3B 416-424 (HLA-A*11:01; HLA-A*68:01) IVTDFSVIK

Product number: EP11151_1

€ 105.00 *

Prices excl. VAT plus shipping costs
Available, delivery time: 1-3 days
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity: 95% HPLC-MS
Caution: For research use only. Not for use in humans.
Amount in mg
1
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Description

The EBV EBNA-3B 416–424 peptide (IVTDFSVIK), historically referenced as EBNA-4 416–424, is one of the most immunodominant and extensively characterized CD8+ T-cell targets in viral immunology. Derived from Epstein-Barr nuclear antigen 3B (EBNA-3B / EBNA-4; UniProt: P03203; epitope ID: 29466) of Epstein-Barr Virus (EBV / Human Herpesvirus 4), this nonamer sequence represents a major cytotoxic target during latent viral infection. 

Featuring the amino acid sequence IVTDFSVIK, this peptide is predominantly presented via the HLA-A3 supertype (specifically HLA-A*11:01 and HLA-A*68:01), making it a high-value tool for broad population-wide immune profiling.

Key Features & Benefits

  • Broad HLA-A Supertype Restriction: Dual-restricted by HLA-A*11:01 and HLA-A*68:01 alleles, providing high population coverage across diverse demographic cohorts.
  • Extensively Validated Benchmark: Backed by a large evidence base of 55 peer-reviewed publications, 105 functional T-cell assays, and 21 MHC ligand binding studies.
  • Core Control Component: Integrated as an essential reference constituent in peptides&elephants' EBV Control Peptide Pool, CEF (Classic) Peptide Pool, and CEF (Advanced) Peptide Pool (>95% HPLC purity).

Applications

  • EBV Latent Phase Immunomonitoring: Measures functional CD8+ T-cell memory (IFN-gamma, TNF-alpha, CD107a) directed against latent nuclear antigens in human PBMCs.
  • Recall Controls & Assay Standardization: Serves as a gold-standard positive control in ELISpot, Fluorospot, and Intracellular Cytokine Staining (ICS) assays.
  • MHC Multimer & Tetramer Staining: Ideal reference ligand for generating HLA-A*11:01 and HLA-A*68:01 peptide-MHC complexes to isolate and enumerate antigen-specific CD8+ T cells.

TechData

Sequence: IVTDFSVIK
Gene: EBNA
Delivery: 1-3 days
C-Terminus: OH
N-Terminus: H
Amount: 1 mg
Counterion: TFA
Protein: Epstein-Barr nuclear antigen
UniProt Id: P03203
IEDB Id: 29466
Species: Epstein-Barr virus (EBV; Human herpesvirus 4)
Allele: HLA-A*11:01, HLA-A*68:01
Application: T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication: Infectious disease, Cancer, Neuroscience
Purity: 95% HPLC-MS

Documents

Material data sheet Safety data sheet Storage and handling of peptides Probing of membranes with HRP
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