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Structure of Influenza A HA 306-318 (DRB1*01:01)

Infectious disease

Influenza A HA 306-318 (DRB1*01:01) PKYVKQNTLKLAT

Product number: EP07851_5

€213.20*

Prices excl. VAT plus shipping costs

Available, delivery time: 1-3 days

sterile and endotoxin free

Delivery Format: The product is supplied freeze dried.

Purity: 95% HPLC-MS

Caution: For research use only. Not for use in humans.

Amount in mg

1

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Description

The Influenza A HA 306–318 Peptide (PKYVKQNTLKLAT) is one of the most thoroughly characterized promiscuous CD4+ T-cell epitopes in viral immunology. Derived from the HA1 subunit of Influenza A Hemagglutinin (strain A/Aichi/2/1968 H3N2; UniProt: P03437), this 13-mer sequence is a benchmark tool for studying broad MHC Class II restriction, helper T-cell activation, and cross-reactive immunity.

Indexed under IEDB Epitope ID 48237, this sequence has been featured in over 130 peer-reviewed publications and structurally validated in multiple Protein Data Bank (PDB) co-crystal structures (e.g., 1DLH, 1FYT, 1HXY). It exhibits exceptionally broad binding across numerous human HLA-DR alleles, making it an ideal reference peptide for population-wide immunomonitoring, ELISPOT controls, and vaccine development assays.

Key Features & Applications

Highly Promiscuous Class II Target: Binds with high affinity across a broad spectrum of HLA-DR alleles, including HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*11:01, HLA-DRB1*07:01, and HLA-DRB5*01:01.
Gold-Standard Reference Epitop: Extensively benchmarked in functional CD4+ T-cell activation assays (ELISPOT, ICS, proliferation) and direct MHC ligand binding studies.
Structural Proof: High-resolution 3D crystal structures available in the PDB demonstrate its precise molecular interactions within the MHC Class II binding groove.

TechData

Sequence:	PKYVKQNTLKLAT
Gene:	HA
Delivery:	1-3 days
C-Terminus:	OH
N-Terminus:	H
Amount:	5 mg
Counterion:	TFA
Protein:	Hemagglutinin
UniProt Id:	P03437
IEDB Id:	48237
Species:	Influenza A virus
Allele:	HLA-DRB101:01, HLA-DRB104:01, HLA-DRB111:01, HLA-DRB107:01, HLA-DR1, HLA-DRB501:01, HLA-DRA01:01/DRB101:01, HLA-DRA01:01/DRB104:01, HLA-DRB104:05, HLA-DR7, HLA-DRB1*13:02, and more
Application:	Antigen specific T-cell stimulation, T-cell assays, T-cell expansion
Indication:	Infectious disease
Purity:	95% HPLC-MS

Documents

Storage and handling of peptides

Probing of membranes with HRP

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