Neuroscience
MOG 92-106 DEGGYTCFFRDHSYQ
Product number: EP09834_1
€133.20*
Prices excl. VAT plus shipping
costs
Available, delivery time:
3 weeks
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity:
95% HPLC-MS
Caution:
For research use only. Not for use in humans.
Amount in mg
1
Description
The myelin oligodendrocyte glycoprotein (MOG) is a clinically significant component of central nervous system (CNS) myelin, and a major focus of neuroimmunology research. Peptides&elephants‘ MOG 92–106 peptide (epitope ID 112472) with the amino acid sequence DEGGYTCFFRDHSYQ is studied as part of mouse MOG (UniProt ID: Q61885) and rat MOG (UniProt ID: Q63345). The peptide has an encephalitogenic effect in rodent models of experimental autoimmune encephalomyelitis (EAE).
Scientists developed transgenic, relapsing-remitting mice (RR mice) carrying a t cell receptor (TCR) specific for MOG 92–106. When backcrossed to the SJL/J mouse strain, most RR mice spontaneously develop relapsing-remitting EAE, with alternating inflammatory episodes affecting different CNS regions such as the cerebellum, optic nerve, and spinal cord. The development of spontaneous EAE in this model depends on an intact B cell compartment and on the expression of MOG autoantigen.
MOG 92–106 supports studies of T- and B-cell reactivity, antigen–antibody binding, and CNS autoimmunity mechanisms. High-purity synthetic material from peptides&elephants ensures suitability for advanced immunology applications including in vitro assays, epitope-specific research and translational neuroimmunology investigations.
Applications:
- Experimental autoimmune encephalomyelitis (EAE) induction and modelling of CNS demyelination
- T cell epitope mapping and specificity studies
- Antigen–antibody interaction research and epitope binding assays
- Investigation of neuroimmune crosstalk and demyelinating pathology
TechData
| Sequence: | DEGGYTCFFRDHSYQ |
| Gene: | mog |
| Delivery: | 3 weeks |
| C-Terminus: | OH |
| N-Terminus: | H |
| Amount: | 1 mg |
| Counterion: | TFA |
| Protein: | Myelin-oligodendrocyte glycoprotein |
| Species: | Mouse, Rat |
| Indication: | Neuroscience |
| Purity: | 95% HPLC-MS |
Documents
References
Tsunoda, I et al. “Antibody association with a novel model for primary progressive multiple sclerosis: induction of relapsing-remitting and progressive forms of EAE in H2s mouse strains.” Brain pathology (Zurich, Switzerland) vol. 10,3 (2000): 402-18. doi:10.1111/j.1750-3639.2000.tb00272.x
Pöllinger, Bernadette et al. “Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells.” The Journal of experimental medicine vol. 206,6 (2009): 1303-16. doi:10.1084/jem.20090299
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From
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From
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Multiple Sclerosis: MOG 94 - 110 induced experimental autoimmune encephalomyelitis (EAE) rodent modelsMyelin oligodendrocyte glycoprotein (MOG)94 - 110, a minor component of CNS myelin, is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 94 - 110 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. This Cysteine containing MOG 94 - 110 peptide can be use to induced polyclonal anti-MOG 94 - 110 antibody production in rabbits with high specificity, high affinity, and high titer indicating its high purity, as well as suitability for peptide-coated ELISA and Western blot assay. Immunization with MOG 94 - 110 suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP. Multiple Sclerosis: MOG 94 - 110 induced experimental autoimmune encephalomyelitis (EAE) rodent modelsMyelin oligodendrocyte glycoprotein (MOG)94 - 110, a minor component of CNS myelin, is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 94 - 110 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. This Cysteine containing MOG 94 - 110 peptide can be use to induced polyclonal anti-MOG 94 - 110 antibody production in rabbits with high specificity, high affinity, and high titer indicating its high purity, as well as suitability for peptide-coated ELISA and Western blot assay. Immunization with MOG 94 - 110 suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP. Multiple Sclerosis: MOG 94 - 110 induced experimental autoimmune encephalomyelitis (EAE) rodent modelsMyelin oligodendrocyte glycoprotein (MOG)94 - 110, a minor component of CNS myelin, is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 94 - 110 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. 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Myelin oligodendrocyte glycoprotein (MOG)96 - 108, a minor component of CNS myelin, is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 96 - 108 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. This Cysteine containing MOG 96 - 108 peptide can be use to induced polyclonal anti-MOG 96 - 108 antibody production in rabbits with high specificity, high affinity, and high titer indicating its high purity, as well as suitability for peptide-coated ELISA and Western blot assay. Immunization with MOG 96 - 108 suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP. 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Immunization with MOG 96 - 108 suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP. Multiple Sclerosis: MOG 96 - 108 induced experimental autoimmune encephalomyelitis (EAE) rodent modelsMyelin oligodendrocyte glycoprotein (MOG)96 - 108, a minor component of CNS myelin, is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 96 - 108 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. This Cysteine containing MOG 96 - 108 peptide can be use to induced polyclonal anti-MOG 96 - 108 antibody production in rabbits with high specificity, high affinity, and high titer indicating its high purity, as well as suitability for peptide-coated ELISA and Western blot assay. Immunization with MOG 96 - 108 suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP. Multiple Sclerosis: MOG 96 - 108 induced experimental autoimmune encephalomyelitis (EAE) rodent modelsMyelin oligodendrocyte glycoprotein (MOG)96 - 108, a minor component of CNS myelin, is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 96 - 108 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. This Cysteine containing MOG 96 - 108 peptide can be use to induced polyclonal anti-MOG 96 - 108 antibody production in rabbits with high specificity, high affinity, and high titer indicating its high purity, as well as suitability for peptide-coated ELISA and Western blot assay. Immunization with MOG 96 - 108 suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP. Multiple Sclerosis: MOG 96 - 108 induced experimental autoimmune encephalomyelitis (EAE) rodent modelsMyelin oligodendrocyte glycoprotein (MOG)96 - 108, a minor component of CNS myelin, is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 96 - 108 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. This Cysteine containing MOG 96 - 108 peptide can be use to induced polyclonal anti-MOG 96 - 108 antibody production in rabbits with high specificity, high affinity, and high titer indicating its high purity, as well as suitability for peptide-coated ELISA and Western blot assay. Immunization with MOG 96 - 108 suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP. Multiple Sclerosis: MOG 96 - 108 induced experimental autoimmune encephalomyelitis (EAE) rodent modelsMyelin oligodendrocyte glycoprotein (MOG)96 - 108, a minor component of CNS myelin, is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 96 - 108 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. This Cysteine containing MOG 96 - 108 peptide can be use to induced polyclonal anti-MOG 96 - 108 antibody production in rabbits with high specificity, high affinity, and high titer indicating its high purity, as well as suitability for peptide-coated ELISA and Western blot assay. Immunization with MOG 96 - 108 suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP. Multiple Sclerosis: MOG 96 - 108 induced experimental autoimmune encephalomyelitis (EAE) rodent modelsMyelin oligodendrocyte glycoprotein (MOG)96 - 108, a minor component of CNS myelin, is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 96 - 108 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. This Cysteine containing MOG 96 - 108 peptide can be use to induced polyclonal anti-MOG 96 - 108 antibody production in rabbits with high specificity, high affinity, and high titer indicating its high purity, as well as suitability for peptide-coated ELISA and Western blot assay. Immunization with MOG 96 - 108 suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP. Multiple Sclerosis: MOG 96 - 108 induced experimental autoimmune encephalomyelitis (EAE) rodent models
MOG 97-108
From
€133.20*
Myelin oligodendrocyte glycoprotein (MOG)97 - 108, a minor component of CNS myelin, is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 97 - 108 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. This Cysteine containing MOG 97 - 108 peptide can be use to induced polyclonal anti-MOG 97 - 108 antibody production in rabbits with high specificity, high affinity, and high titer indicating its high purity, as well as suitability for peptide-coated ELISA and Western blot assay. Immunization with MOG 97 - 108 suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.
Multiple Sclerosis: MOG 97 - 108 induced experimental autoimmune encephalomyelitis (EAE) rodent modelsMyelin oligodendrocyte glycoprotein (MOG)97 - 108, a minor component of CNS myelin, is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 97 - 108 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. This Cysteine containing MOG 97 - 108 peptide can be use to induced polyclonal anti-MOG 97 - 108 antibody production in rabbits with high specificity, high affinity, and high titer indicating its high purity, as well as suitability for peptide-coated ELISA and Western blot assay. Immunization with MOG 97 - 108 suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.
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MOG Peptide Pool, human
€237.50*
Pool of 59 peptides derived from a peptide scan (15mers with 11 aa overlap) through Myelin-oligodendrocyte glycoprotein (Uni-Prot ID Q16653) of Homo sapiens (Human).
One unit allows the stimulation of 2,5 x 108 cells.