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Structure of [beta]-Amyloid (1-28)
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Neuroscience

[beta]-Amyloid (1-28) DAEFRHDSGYEVHHQKLVFFAEDVGSNK

Product number: EP10027_5

€332.90*

Prices excl. VAT plus shipping costs
Available, delivery time: 3 weeks
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity: 95% HPLC-MS
Caution: For research use only. Not for use in humans.
Amount in mg
1
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Description

The three-dimensional solution structure of Aß (1-28) reveals the folding of the peptide to form a predominantly a-helical structure with a bend centered at residue 12 and the side chains of histidine-13 and lysine-16 in close proximity, residing on the same face of the helix. Their proximity may constitute a binding motif with the heparan sulfate proteoglycans. Aß (1-28) is highly hydrophilic and shares sequences with bA4, the major component of Aß. Its assembly is fibrillar, i.e., elongated in a single direction. Reports show that synthetic peptides Aß (1-40) and Aß (1-28) have significant effects on normal human plasma cholesterol esterification rate. Both peptides (at concentration of 1 ng/mL) inhibit plasma cholesterol esterification rate by 40-50% compared to the control value.

TechData

Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNK
Gene: APP
Delivery: 3 weeks
C-Terminus: OH
N-Terminus: H
Amount: 5 mg
Counterion: TFA
Protein: Amyloid-beta precursor protein
UniProt Id: P05067
IEDB Id: 99923
Species: Human
Application: ELISPOT, Flow Cytometry, Western Blotting
Indication: Neuroscience
Purity: 95% HPLC-MS

Documents

Material data sheet Safety data sheet Storage and handling of peptides Probing of membranes with HRP
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