[beta]-Amyloid (12-28)
Injection of the amyloid ?-protein fragment VHHQKLVFFAEDVGSNK into different limbic system structures in mice impaired retention with remarkably similar efficacy and in a dose-dependent manner. A? (12-28) and other A? fragments may exert dysregulatory cognitive effects by incoordination of K? channel function in neurons, glia and endothelial cells. A� (12�28) residues are the binding site for apolipoprotein E (apoE) on A�. This sequence encompasses a hydrophobic domain (residues 14�21) and a �-turn (residues 22�28) which place two hydrophobic domains of A� 14 to 21 and 29 to 40/42 opposite each other, allowing for the assembly of A� peptides into fibrils. The secondary structure of A� (12- 28), a neutral peptide, is dominated by a-helix and random coil. The interaction of apoE with residues 12 to 28 of A� is not just a non-specific hydrophobic interaction but plays a pivotal role in the mechanism of A� pathology in Alzheimer�s disease (AD). A� (11-28) and five other fragments enhanced aggregation of full length A� (1-40). All of the peptides that enhance aggregation contained either residues 17 to 20 or 30 to 35, indicating the importance of these regions for promoting aggregation of full-length A�.
| Sequence: | VHHQKLVFFAEDVGSNK | |
| Gene: | APP | |
| Delivery: | 3 weeks | |
| C-Terminus: | OH | |
| N-Terminus: | H | |
| Amount: | 1 mg | |
| Counter Ion: | TFA | |
| Protein: | Amyloid-beta precursor protein | |
| Species: | Human | |
| Allele: | ||
| Application : | Neuroscience | |
| Indication : | Alzheimer's Disease | |
| Purity : | 95% HPLC-MS |
Protocols and Tips
Data sheets
Safety data sheet poly peptides:For your convenience, we have compiled a selection of publications
where our peptide products have been employed:
Publications >
€84.55*
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity: 95% HPLC-MS