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Structure of EBV EBNA 3B 399-408 (HLA-A*11:01)
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Infectious disease

EBV EBNA 3B 399-408 (HLA-A*11:01) AVFDRKSDAK

Product number: EP11150_1

€ 105.00 *

Prices excl. VAT plus shipping costs
Available, delivery time: 3 weeks
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity: 95% HPLC-MS
Caution: For research use only. Not for use in humans.
Amount in mg
1
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Description

The EBV EBNA-3B 399–408 peptide (AVFDRKSDAK), historically also known as EBNA-4 399–408, is one of the most thoroughly validated CD8+ T-cell targets derived from Epstein-Barr nuclear antigen 3B (EBNA-3B / EBNA-4; UniProt: P03203; epitope ID: 5316) of Epstein-Barr Virus (EBV / Human Herpesvirus 4). 

Expressed during latent phase III infection, EBNA-3B triggers potent cytotoxic T-lymphocyte (CTL) responses. Primary presentation occurs via HLA-A*11:01, though functional literature also confirms presentation via HLA-A*03:01, providing high population coverage for human immunomonitoring assays.

Key Features & Benefits

  • Dual HLA-A Supertype Recognition: Primarily restricted by HLA-A*11:01 and cross-validated for presentation on HLA-A*03:01, enabling broad applicability across diverse demographic cohorts.
  • Exceptionally Benchmark-Validated: Supported by an extensive evidence base of 41 peer-reviewed publications, 80 functional T-cell assays, and 13 MHC ligand binding studies.
  • Core Control Component: Integrated as a key reference constituent in peptides&elephants' EBV Control Peptide Pool and CEF (Advanced) Peptide Pool (>95% HPLC purity).

Applications

  • EBV Latent Phase Immunomonitoring: Quantifies functional cytotoxic CD8+ T-cell memory (IFN-gamma, TNF-alpha, CD107a) directed against latent viral targets in human PBMCs.
  • Recall Controls & Assay Standardization: Serves as a gold-standard positive control in ELISpot, Fluorospot, and Intracellular Cytokine Staining (ICS) assays.
  • MHC Multimer & Tetramer Staining: Ideal reference ligand for generating HLA-A*11:01 and HLA-A*03:01 peptide-MHC complexes to isolate and enumerate antigen-specific CD8+ T cells.

TechData

Sequence: AVFDRKSDAK
Gene: EBNA
Delivery: 3 weeks
C-Terminus: OH
N-Terminus: H
Amount: 1 mg
Counterion: TFA
Protein: Epstein-Barr nuclear antigen
UniProt Id: P03203
IEDB Id: 5316
Species: Epstein-Barr virus (EBV; Human herpesvirus 4)
Allele: HLA-A*11:01
Application: Flow Cytometry, Immunohistochemistry
Indication: Infectious disease, Cancer, Neuroscience
Purity: 95% HPLC-MS

Documents

Material data sheet Safety data sheet Storage and handling of peptides Probing of membranes with HRP
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