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Structure of Influenza A NP 383-391 (HLA-B*27:05)
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Infectious disease

Influenza A NP 383-391 (HLA-B*27:05) SRYWAIRTR

Product number: EP11318_5

€210.00*

Prices excl. VAT plus shipping costs
Available, delivery time: 1-3 days
sterile and endotoxin free
Delivery Format: The product is supplied freeze dried.
Purity: 95% HPLC-MS
Caution: For research use only. Not for use in humans.
Amount in mg
1
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Description

The Influenza A NP 383–391 peptide (Sequence: SRYWAIRTR) is an exceptionally well-studied, immunodominant epitope derived from the viral Nucleoprotein (NP) of Influenza A virus (UniProt ID: P03466). 

Primarily presented by HLA-B*27:05, this canonical peptide is a cornerstone tool in cellular immunology for monitoring CD8+ cytotoxic T-lymphocyte (CTL) activation, investigating viral immune escape, and profiling allele-specific T-cell responses. Reactivity has additionally been reported in select studies for related alleles, including HLA-B*27:03 and HLA-B*27:04.

Key Scientific Highlights 

  • Extensive Literature Validation: Supported by an exceptional scientific corpus including 58 publications, 74+ functional T-cell assays, and 75 MHC ligand binding studies (IEDB Epitope ID: 60867). 
  • High-Resolution Structural Data: Structural binding interactions are fully resolved in available 3D crystal structures (PDB ID: 2BST), facilitating structure-based TCR interaction studies. 
  • Recall Assay Reference: Widely recognized as a benchmark viral antigen for testing memory T-cell responses in HLA-B*27-positive donor samples. 

Cross-Referenced Control Pools 

Streamline your assay workflows by sourcing this epitope as an individual catalog peptide or as a verified component within our off-the-shelf peptides&elephants control panels: 

TechData

Sequence: SRYWAIRTR
Gene: NP
Delivery: 1-3 days
C-Terminus: OH
N-Terminus: H
Amount: 1 mg
Counterion: TFA
Protein: Nucleoprotein
UniProt Id: P03466
Species: Influenza A virus
Allele: HLA-B*27:05
Application: T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response
Indication: Infectious disease
Purity: 95% HPLC-MS

Documents

Material data sheet Safety data sheet Storage and handling of peptides Probing of membranes with HRP

References

Boon, A C M et al. “The magnitude and specificity of influenza A virus-specific cytotoxic T-lymphocyte responses in humans is related to HLA-A and -B phenotype.” Journal of virology vol. 76,2 (2002): 582-90. doi:10.1128/jvi.76.2.582-590.2002

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